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Mesenteric fat lipolysis mediates obesity associated hepatic steatosis and insulin resistance: Mesenteric Fat Lipolysis Mediates Obesity-associated Hepatic Steatosis and Insulin Resistance

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William Murphy
Tuesday, March 5, 2019
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Hepatic steatosis and insulin resistance are among the ane prevalent metabolic disorders and tightly associated with obesity and type 2 diabetes. Nat Commun12 120 May In obese mice, adipocyte-specific gp deletion reduced basal lipolysis and enhanced insulin's ability to suppress lipolysis from mesenteric but not epididymal adipocytes. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. Recent history Saved searches.

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Report the problem now and we will take corresponding actions after reviewing your request. Smart citations by scite. Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and tightly associated with obesity and type 2 associaed. This website requires cookies, and the limited processing of your personal data in order to function. Abstract Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and are tightly associated with obesity and type 2 diabetes. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles. Publisher 'American Diabetes Association'.

In fact, one provocative idea is that the immune response on beta cells in type-1 and type-2 diabetes could be initiated by PAT [ 22 ]. Blue is used for terms that have a relation with the terms in this document, but occur in other documents. Skeletal muscle and whole body insulin resistance but not cardiac muscle insulin resistance could be improved by troglitazone therapy within 12 weeks in type-2 diabetes. Therefore, blocking IL-6 cytokine signaling in mesenteric adipocytes may be a novel approach to blunting detrimental fat-liver crosstalk in obesity. Furthermore, PAT-ectomized mice displayed more severe HFD-induced hepatic steatosis than controls; the liver weights were increased Fig. The relative difference in fat depot weight between HFD- and chow-fed mice at 16 weeks was reduced compared to the 8-week HFD group. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License.

Blocking gp signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity. J Biol Chem3410 Jul Therefore, blocking IL-6 cytokine signaling in mesenteric adipocytes may be a novel approach to blunt detrimental fat-liver crosstalk in obesity. However, underlying mechanism linking obesity to hepatic lipid accumulation and insulin resistance are incompletely understood. I agree, dismiss this banner. Mouse-hovering a term displays its timeline, clicking it yields the associated documents. Free to read.

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Users please log in : Suggest update or correction for this item. Our results demonstrate that IL-6 steztosis lipolysis may be restricted to mesenteric WAT and that it contributes to hepatic insulin resistance and steatosis. This website requires cookies, and the limited processing of your personal data in order to function. J Biol Chem3410 Jul Sci Rep10 110 Jun

Herein, we provide evidence that gpmediated adipose tissue lipolysis promotes hepatic steatosis and insulin resistance. Downloads 99 downloads since deposited on 15 Dec 21 downloads since 12 months Detailed statistics. J Biol Chem3410 Jul Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases. Glycoprotein gp is the common signal transducer of all interleukin 6 IL-6 cytokines.

Konrad D 6. Herein, we provide evidence that gpmediated adipose tissue lipolysis promotes hepatic steatosis and insulin resistance. In obese mice, meediates gp deletion reduced basal lipolysis and enhanced insulin's ability to suppress lipolysis from mesenteric but not epididymal adipocytes. Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and are tightly associated with obesity and type 2 diabetes. Therefore, blocking IL-6 cytokine signaling in mesenteric adipocytes may be a novel approach to blunting detrimental fat-liver crosstalk in obesity.

Introduction

As expected, serum insulin levels were greater than fivefold higher in HFD- inxulin chow-fed mice reflecting increased insulin resistance. There were however weak trends toward reduced pancreatic triglyceride content Fig. Accepted : 15 August Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues. Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling.

  • Download references. In general, subcutaneous fat accumulation provokes less metabolic disturbances than visceral adiposity, which is strongly associated with insulin resistance and type-2 diabetes [ 57 ].

  • Semin Liver Dis28 427 Oct

  • Search Search articles by subject, keyword or author.

  • Blocking gp signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity. Abstract Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and tightly associated with obesity and type 2 diabetes.

Ethnic differences in hepatic steatosis: an insulin resistance paradox? In essence, PAT displayed reduced expression of genes related to adipocyte function while mesenteriic expression of macrophage and inflammatory markers was increased along with a higher number of leukocytes including macrophages per gram of tissue. The gene expression profile and the cellular composition in normal chow-diet mice was also different in PAT compared to the other fat depots. However, there was a difference in size distribution with fewer adipocytes of the smallest size and more adipocytes of the medium to large size in the regenerated PAT of PAT-ectomized mice Supplementary Fig. View 6 excerpts, references background. Herein, we provide evidence that gpmediated adipose tissue lipolysis promotes hepatic steatosis and insulin resistance. Mol Metab.

Overview Citation formats. Adipocyte7 303 Aug Users please log in : Suggest update or correction for this item. Smart citations by scite. Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and tightly associated with obesity and type 2 diabetes. This data has been provided by curated databases and other sources that have cited the article.

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Therefore, blocking IL-6 cytokine signaling in mesenteric adipocytes may be a novel approach to blunting detrimental fat-liver crosstalk in obesity. Smart citations by scite. Mol Nutr Food Res65 1 :e, 13 Jul

Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. In fact, one provocative idea is that the immune resistancee on beta cells in type-1 and type-2 diabetes could be initiated by PAT [ 22 ]. Adipose tissue derived-factors impaired pancreatic beta-cell function in diabetes. We attribute these in vivo findings to compensatory beta-cell hyperplasia in response to HFD-induced systemic insulin resistance due to e.

Inverse regulation of basal lipolysis in perigonadal and mesenteric fat depots in mice. Furthermore, PAT-ectomized mice displayed more severe HFD-induced hepatic steatosis than controls; the liver weights were increased Fig. Related Articles: Open Access. Of note, adipocyte-specific gp knockout mice were protected from high-fat diet-induced hepatic steatosis as well as from insulin resistance. The gene expression profile and the cellular composition in normal chow-diet mice was also different in PAT compared to the other fat depots. However, there are also regional differences with respect to lipolysis [ 10 ], fatty acid storage [ 11 ], adipokine secretion [ 6 ], and overall gene expression profile [ 1213 ].

Short-term HFD does not alter lipolytic function of adipocytes. What role do fat cells play in pancreatic tissue? Horm Mol Biol Clin Investig. Article Google Scholar 9.

Contact us. For the other depots, lipplysis such correlation was observed and for GWAT a negative correlation was observed Fig. In obese mice, adipocyte-specific gp deletion reduced basal lipolysis and enhanced insulin's ability to suppress lipolysis from mesenteric but not epididymal adipocytes. Received : 04 December Help Close help TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. View 1 excerpt, references methods.

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To test this we studied the impact of PAT removal on metabolic function and hepatic steatosis Steatsois Fig. View 2 excerpts, references background. View 1 excerpt, references methods. Mouse-hovering a term displays its timeline, clicking it yields the associated documents. Fatty acid binding protein expression in different human adipose tissue depots in relation to rates of lipolysis and insulin concentration in obese individuals. Insulin-sensitive obesity. We attribute these in vivo findings to compensatory beta-cell hyperplasia in response to HFD-induced systemic insulin resistance due to e.

Autologous fecal transplantation from a lean state potentiates caloric restriction effects on body weight and adiposity in obese mice. Overview Citation formats. Publication types Research Support, Non-U. However, underlying mechanism linking obesity to hepatic lipid accumulation and insulin resistance are incompletely understood. Consistently, free fatty acid levels were reduced in portal but not in systemic circulation of obese knockout mice. Herein, we provide evidence that gpmediated adipose tissue lipolysis promotes hepatic steatosis and insulin resistance.

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Having an issue? Read article at publisher's site DOI : Smart citations by scite. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy. Advanced Search Help.

Publisher 'American Diabetes Association'. Help Close help TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. Wueest SKonrad D. Zhao PSaltiel AR. The terms and their relations were extracted from ZORA using word statistics.

Issue Date : Fesistance The hepatic aand of inflammatory markers serum amyloid a1, a2, and a3 Saa1—3as well as markers of insulin resistance such as Glut2 Slc2a2phosphoenolpyruvate carboxylase Pepckand peroxisome proliferator-activated receptor gamma Ppargwere elevated in PAT-ectomized mice compared to controls Fig. The relative difference in fat depot weight between HFD- and chow-fed mice at 16 weeks was reduced compared to the 8-week HFD group. The enhanced hyperinsulinemia in PAT-ectomized mice did not stimulate increased intrapancreatic adipogenesis. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. Oral glucose tolerance test, tissue triglyceride quantification, islet and PAT co-culture, and glucose-stimulated insulin secretion are described in Supplementary methods. In this investigation, we have studied the effects of vasoconstrictors, phenylephrine and noradrenaline, and vasorelaxants, carbachol and s-nitroso-n- acetylpenicillamine SNAPon subclavian and iliac rings with and without PVAT attached; and concentration-response curves were constructed accordingly.

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Similar Articles To arrive at the top five similar mediatws we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. Of note, adipocyte-specific gp knockout mice were protected from high-fat diet-induced hepatic steatosis as well as from insulin resistance. Abstract Read article for free, via Unpaywall a legal, open copy of the full text. Abstract Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and tightly associated with obesity and type 2 diabetes.

Abstract Hepatic steatosis and insulin resistance are among the most prevalent associsted disorders and are tightly associated with obesity and type 2 diabetes. Therefore, blocking IL-6 cytokine signaling in mesenteric adipocytes may be a novel approach to blunt detrimental fat-liver crosstalk in obesity. Nutrients12 1104 Nov Glycoprotein gp is the common signal transducer of all interleukin 6 IL-6 cytokines. To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. J Lipid Res58 1105 Sep Article Networks TrendTerms.

Recent history Saved searches. However, the underlying mechanisms linking obesity to hepatic lipid accumulation and insulin resistance are incompletely understood. Nutrients12 1104 Nov Downloads 99 downloads since deposited on 15 Dec 21 downloads since 12 months Detailed statistics. Publication date January 1,

Lucchini FC 3. Item F 2. Therefore, blocking IL-6 cytokine signaling in mesenteric adipocytes may be a novel approach to blunting detrimental fat-liver crosstalk in obesity.

In contrast, there was no correlation between body weight and GWAT and body weight and MWAT, possibly indicating that these depots have reached their maximal size and cannot expand further Supplementary Table 2. View 4 excerpts, references background. Conclusions PAT is a small metabolically highly active fat depot that plays a previously unrecognized role in the pathogenesis of hepatic steatosis and insulin resistance in advanced obesity. Importantly, adipocyte-specific gp knockout mice were protected from high fat diet HFD -induced hepatic steatosis as well as insulin resistance.

Full size image. Am J Physiol Endocrinol Metab. Lipolysos J Obes 44, — Item and Fabrizio C. Pearson r correlation was used to measure the degree of the relationship between adipose tissue and liver weights. Of note, adipocyte-specific gp knockout mice were protected from high-fat diet-induced hepatic steatosis as well as from insulin resistance.

Adipose tissue inflammation contributes to short-term high-fat diet-induced hepatic insulin resistance. Diabetes17 Sep65 1 : DOI: I agree, dismiss this banner. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. Smart citations by scite.

Help Close help TrendTerms displays relevant terms steatsis the abstract of this publication and related documents on a map. We provide evidence that gpmediated adipose tissue lipolysis promotes hepatic steatosis and insulin resistance. This data has been provided by curated databases and other sources that have cited the article. Mouse-hovering a term displays its timeline, clicking it yields the associated documents. This website requires cookies, and the limited processing of your personal data in order to function.

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  • Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and tightly associated with obesity and type 2 diabetes.

  • Is data on this page outdated, violates copyrights or anything else?

  • Our results demonstrate that IL-6 cytokine-induced lipolysis may be restricted to mesenteric WAT and that it contributes to hepatic insulin resistance and steatosis.

  • Our results demonstrate that IL-6 cytokine-induced lipolysis may be restricted to mesenteric WAT and that it contributes to hepatic insulin resistance and steatosis. Consistently, free fatty acid levels were reduced in portal but not in systemic circulation of obese knockout mice.

I agree, dismiss this banner. Help Close help TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. Abstract Read article for free, via Unpaywall a legal, open copy of the full text. Mol Nutr Food Res65 1 :e, 13 Jul In obese mice, adipocyte-specific gp deletion reduced basal lipolysis and enhanced insulin's ability to suppress lipolysis from mesenteric but not epididymal adipocytes.

Intrapancreatic adipocytes appear to arise within pancreas primarily when conditions are sufficiently adipogenic such as in response to high-fat diet HFD feeding in mice [ 151617 ]. However, the islet-preserving effect of PAT could also stem from reduced glucotoxicity due to the competition for nutrients at co-culture conditions. Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and tightly associated with obesity and type 2 diabetes. Our results demonstrate that IL-6 cytokine-induced lipolysis may be restricted to mesenteric WAT and that it contributes to hepatic insulin resistance and steatosis. Journal of Biomedical Science and Engineering Vol.

Therefore, blocking IL-6 cytokine signaling in mesenteric adipocytes may be a novel approach to blunting detrimental fat-liver crosstalk in obesity. Glycoprotein gp is the common signal transducer of all interleukin 6 IL-6 cytokines. Our results demonstrate that IL-6 cytokine-induced lipolysis may be restricted to mesenteric WAT and that it contributes to hepatic insulin resistance and steatosis. In obese mice, adipocyte-specific gp deletion reduced basal lipolysis and enhanced insulin's ability to suppress lipolysis from mesenteric but not epididymal adipocytes.

Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and tightly associated with obesity and type 2 diabetes. Data Data that cites the article This data has been provided by curated databases and other sources that have cited the article. Of note, adipocyte-specific gp knockout mice were protected from high-fat diet-induced hepatic steatosis as well as from insulin resistance. We provide evidence that gpmediated adipose tissue lipolysis promotes hepatic steatosis and insulin resistance. Search articles by 'Flurin Item'. In the latter case, please turn on Javascript support in your web browser and reload this page.

You can navigate and zoom the map. Consistently, free fatty acid levels were reduced in portal but not in systemic circulation of obese knockout mice. Konrad D 6. In obese mice, adipocyte-specific gp deletion reduced basal lipolysis and enhanced insulin's ability to suppress lipolysis from mesenteric but not epididymal adipocytes. In obese mice, adipocyte-specific gp deletion reduced basal lipolysis and enhanced insulin's ability to suppress lipolysis from mesenteric but not epididymal adipocytes.

Having an issue? Nat Commun12 120 May Help Close help TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. Importantly, adipocyte-specific gp knockout mice were protected from high fat diet HFD -induced hepatic steatosis as well as insulin resistance. The results show that IL-6 cytokine-induced lipolysis may be restricted to mesenteric white adipose tissue and that it contributes to hepatic insulin resistance and steatosis.

Blocking gp signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity. Mouse-hovering a term displays its timeline, clicking it yields the associated documents. You can navigate and zoom the map. Herein, we provide evidence that gpmediated adipose tissue lipolysis promotes hepatic steatosis and insulin resistance. We provide evidence that gpmediated adipose tissue lipolysis promotes hepatic steatosis and insulin resistance.

Search Search articles by subject, keyword or author. JavaScript is required to view the contents of this page. Publish with us. The reason for this relative reduction is due to significant fat mass gain also in the ad libitum chow-fed controls Supplementary Table 1. References 1.

We provide evidence that gpmediated adipose tissue lipolysis promotes hepatic steatosis and insulin resistance. Zhao PSaltiel AR. Consistently, free fatty acid levels were reduced in portal but not in systemic circulation of obese knockout mice. Abstract Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and are tightly associated with obesity and type 2 diabetes. Consistently, free fatty acid levels were reduced in portal but not in systemic circulation of obese knockout mice.

Ann Med. However, the underlying mechanisms linking obesity to hepatic lipid accumulation and insulin resistance are incompletely understood. View 2 excerpts, references background. Pancreatic adipocytes mediate hypersecretion of insulin in diabetes-susceptible mice. Show results from All journals This journal.

Data are expressed relative to the level in PAT. The associated of PVAT on the functional activity of the vascular bed has been a matter abc news normal weight obesity definition debate, whether it is an anticontractile effect with protective roles or a pro-contractile effect, investigations are underway to address this obscurity. Publication Type. It has also been shown that obesity- and diabetes-induced changes in PAT, but not gonadal GWAT and inguinal white adipose tissues IWATsecretome increase beta-cell proliferation in vitro [ 2021 ]. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. For the aqueous phase at least in part reflecting glucose oxidationthe highest 14 C counts were found in PAT where levels were tenfold higher than in GWAT in mice on chow Fig.

Diabetes, 65 1 Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the seatosis is not altered. Abstract Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and tightly associated with obesity and type 2 diabetes. In obese mice, adipocyte-specific gp deletion reduced basal lipolysis and enhanced insulin's ability to suppress lipolysis from mesenteric but not epididymal adipocytes. Abstract Read article for free, via Unpaywall a legal, open copy of the full text.

Skip to search form Skip to main content You are currently offline. JavaScript is required to view resisfance contents of this page. Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice. In addition, histology analysis revealed characteristics of white adipose tissue in both PVATs.

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In obese mice, adipocyte-specific gp deletion reduced basal lipolysis and enhanced insulin's ability to suppress lipolysis from mesenteric but not epididymal adipocytes. Pancreas fat and beta cell mass in humans with and without diabetes: an analysis in the Japanese population. Cell Metab. Show results from All journals This journal. In addition, histology analysis revealed characteristics of white adipose tissue in both PVATs. View 1 excerpt, references background. PAT was distinguished from the other fat depots by increased glucose uptake and increased fatty acid oxidation in both lean and obese mice.

Abstract Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders associated are tightly associated with obesity and type 2 diabetes. This data has been provided by curated databases and other sources that have cited the article. Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and tightly associated with obesity and type 2 diabetes. The results show that IL-6 cytokine-induced lipolysis may be restricted to mesenteric white adipose tissue and that it contributes to hepatic insulin resistance and steatosis. Therefore, blocking IL-6 cytokine signaling in mesenteric adipocytes may be a novel approach to blunt detrimental fat-liver crosstalk in obesity. Search articles by 'Fabrizio C Lucchini'.

Adipose tissue inflammation contributes to short-term high-fat diet-induced aft insulin resistance. In obese mice, adipocyte-specific gp deletion reduced basal lipolysis and enhanced insulin's ability to suppress lipolysis from mesenteric but not epididymal adipocytes. However, underlying mechanism linking obesity to hepatic lipid accumulation and insulin resistance are incompletely understood. Explore citation contexts and check if this article has been supported or disputed.

Challa, Tenagne D. In obese mice, adipocyte-specific gp deletion reduced basal lipolysis and enhanced insulin's ability to suppress lipolysis associaated mesenteric but not epididymal adipocytes. J Lipid Res58 1105 Sep To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. Glycoprotein gp is the common signal transducer of all interleukin 6 IL-6 cytokines. Of note, adipocyte-specific gp knockout mice were protected from high-fat diet-induced hepatic steatosis as well as from insulin resistance. Our results demonstrate that IL-6 cytokine-induced lipolysis may be restricted to mesenteric WAT and that it contributes to hepatic insulin resistance and steatosis.

Received : 04 December Insulin-sensitive obesity. In essence, PAT displayed reduced expression of genes related to adipocyte function while the expression of macrophage and inflammatory markers was increased along with a higher number of leukocytes including macrophages per gram of tissue. For the aqueous phase at least in part reflecting glucose oxidationthe highest 14 C counts were found in PAT where levels were tenfold higher than in GWAT in mice on chow Fig. Nat Med.

Explore citation contexts and check if this article has been supported or disputed. Lucchini, Fabrizio C. Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and are tightly associated with obesity and type 2 diabetes. This is an author-created, uncopyedited electronic version of an article accepted for publication in Diabetes.

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  • In obese mice, adipocyte-specific gp deletion reduced basal lipolysis and enhanced insulin's ability to suppress lipolysis from mesenteric but not epididymal adipocytes. Is data on this page outdated, violates copyrights or anything else?

  • The American Diabetes Association ADApublisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties.

  • The results show that IL-6 cytokine-induced lipolysis may be restricted to mesenteric white adipose tissue and that it contributes to hepatic insulin resistance and steatosis.

  • Show results from All journals This journal. Metab Clin Exp.

Glycoprotein gp is the common signal transducer of all interleukin 6 IL-6 cytokines. This stetosis was published in ZORA. Role of fatty acids in the pathogenesis of obesity and fatty liver: impact of bariatric surgery. Help Close help TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. TrendTerms displays relevant terms of the abstract of this publication and related documents on a map.

Associxted note, adipocyte-specific gp knockout mice were protected from high-fat diet-induced hepatic steatosis as well as from insulin resistance. However, underlying mechanism linking obesity to hepatic lipid accumulation and insulin resistance are incompletely understood. Europe PMC requires Javascript to function effectively. Cited by: 39 articles PMID: Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. You can navigate and zoom the map. However, the underlying mechanisms linking obesity to hepatic lipid accumulation and insulin resistance are incompletely understood.

Glycoprotein gp is the common signal transducer of all interleukin 6 IL-6 cytokines. However, underlying mechanism linking obesity to hepatic lipid accumulation and insulin resistance are incompletely understood. View graph of relations. Recent history Saved searches.

  • In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues.

  • Mol Nutr Food Res65 1 :e, 13 Jul

  • The hepatic expression of inflammatory markers serum amyloid a1, a2, and a3 Saa1—3as well as markers of insulin resistance such as Glut2 Slc2a2phosphoenolpyruvate carboxylase Pepckand peroxisome proliferator-activated receptor gamma Ppargwere elevated in PAT-ectomized mice compared to controls Fig. Consequently, hepatic steatosis suggests that excess calories are not efficiently stored in adipose tissue, possibly reflecting adipocyte insulin resistance and inability to expand the fat depots.

  • Despite similar relative fat depot weight gain during the first 8 weeks on HFD, the gene expression pattern was different in PAT compared to the other fat depots.

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Consistently, free fatty acid levels were reduced in portal but not in systemic circulation of obese mwsenteric mice. Review Free to read. Glycoprotein gp is the common signal transducer of all interleukin 6 IL-6 cytokines. This data has been provided by curated databases and other sources that have cited the article. In obese mice, adipocyte-specific gp deletion reduced basal lipolysis and enhanced insulin's ability to suppress lipolysis from mesenteric but not epididymal adipocytes. However, underlying mechanism linking obesity to hepatic lipid accumulation and insulin resistance are incompletely understood.

The American Diabetes Association ADApublisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. However, underlying mechanism linking obesity to hepatic lipid accumulation and insulin resistance are incompletely understood. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. Consistently, free fatty acid levels were reduced in portal but not in systemic circulation of obese knockout mice. Therefore, blocking IL-6 cytokine signaling in mesenteric adipocytes may be a novel approach to blunt detrimental fat-liver crosstalk in obesity.

Enhanced metabolic flexibility associated with elevated adiponectin levels. Asxociated Furthermore, PAT-ectomized mice displayed more severe HFD-induced hepatic steatosis than controls; the liver weights were increased Fig. DOI: However, lipid oxidation was again highest in PAT Fig. The gene expression profile and the cellular composition in normal chow-diet mice was also different in PAT compared to the other fat depots. Nat Med.

Read article at publisher's site DOI : Challa, Tenagne D. Herein, we provide evidence that gpmediated adipose tissue lipolysis promotes hepatic steatosis and insulin resistance. Item F 2. Adipocyte7 303 Aug

Importantly, adipocyte-specific gp knockout mice were protected from high fat diet HFD -induced hepatic steatosis as well as insulin resistance. CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance. Importantly, adipocyte-specific gp knockout mice were protected from high fat diet HFD -induced hepatic steatosis as well as insulin resistance. Role of fatty acids in the pathogenesis of obesity and fatty liver: impact of bariatric surgery. In the latter case, please turn on Javascript support in your web browser and reload this page. We provide evidence that gpmediated adipose tissue lipolysis promotes hepatic steatosis and insulin resistance. Therefore, blocking IL-6 cytokine signaling in mesenteric adipocytes may be a novel approach to blunting detrimental fat-liver crosstalk in obesity.

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  • Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and tightly associated with obesity and type 2 diabetes. Lucchini, Fabrizio C.

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Explore citation contexts and check if this article has been supported or disputed. Therefore, blocking IL-6 cytokine signaling in mesenteric adipocytes may be a novel approach to blunt detrimental fat-liver crosstalk in obesity. Nat Commun12 120 May Herein, we provide evidence that gpmediated adipose tissue lipolysis promotes hepatic steatosis and insulin resistance.

Create Alert Alert. Article Networks TrendTerms. Our results demonstrate that IL-6 cytokine-induced lipolysis may be restricted to mesenteric WAT and that it contributes to hepatic insulin resistance and steatosis. Download references.

Lipolydis results show that IL-6 cytokine-induced lipolysis may be restricted to mesenteric white adipose tissue and that it contributes to hepatic insulin resistance and steatosis. Cited by: 39 articles PMID: Wueest S 1. Similar Articles To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Cited by: 29 articles PMID: You can navigate and zoom the map. We provide evidence that gpmediated adipose tissue lipolysis promotes hepatic steatosis and insulin resistance. Lucchini, Fabrizio C. The terms and their relations were extracted from ZORA using word statistics.

Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and are tightly associated with obesity and type 2 diabetes. Full size image. View on ADA. Adipocyte death, adipose tissue remodeling, and obesity complications. Research Feed. View 4 excerpts, references background.

In fact, one provocative idea is that the immune response on beta cells in type-1 and type-2 diabetes could be initiated by PAT [ 22 ]. In order to elucidate whether PAT plays a significant role in obesity-associated metabolic disturbances, we surgically removed PAT in lean mice followed by a week long HFD-feeding regimen. The results show that IL-6 cytokine-induced lipolysis may be restricted to mesenteric white adipose tissue and that it contributes to hepatic insulin resistance and steatosis. You need to enable JavaScript to run this app. PAT also displayed relative resistance to the deleterious effects of HFD and the transcriptional changes were not as pronounced as in the other fat depots.

What role do fat cells play in pancreatic tissue? However, the underlying mechanisms linking obesity to hepatic lipid accumulation and insulin resistance are incompletely understood. In contrast, there was no correlation between body weight and GWAT and body weight and MWAT, possibly indicating that these depots have reached their maximal size and cannot expand further Supplementary Table 2. Their timelines are taken from ZORA as well. Mesenteric adipose tissue contributes to intestinal barrier integrity and protects against nonalcoholic fatty liver disease in mice.

The results show that IL-6 cytokine-induced lipolysis may be restricted to mesenteric white adipose tissue and that it contributes to hepatic insulin resistance and steatosis. TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. You can navigate and zoom the map. Toggle navigation ZORA. Glycoprotein gp is the common signal transducer of all interleukin 6 IL-6 cytokines. Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and tightly associated with obesity and type 2 diabetes.

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. Blue is used for terms that have a relation with the terms staetosis this document, but occur in other eteatosis. Adipoq adiponectin, Lep leptin, Scd1 stearoyl-coenzyme A desaturase 1, Fasn fatty acid synthase, Srebp1c sterol regulatory element-binding transcription factor-1c, Chrebp carbohydrate-responsive element-binding protein, Insr insulin receptor, Pparg peroxisome proliferator-activated receptor gamma, Glut4 glucose transporter type 4, B3ar adrenoceptor beta 3, Tnfa tumor necrosis factor alpha, Mcp1 monocyte chemoattractant protein-1, Il1b interleukin-1 beta, Arg1 arginase 1, Cd macrophage mannose receptor C-type 1, Ucp1 uncoupling protein-1, Cpt1b carnitine palmitoyltransferase 1b, Atp6 ATP synthase 6, PAT peripancreatic adipose tissue, MWAT mesenteric adipose tissue, IWAT inguinal adipose tissue, and GWAT gonadal adipose tissue. Adipose tissue fatty acid storage factors: effects of depot, sex and fat cell size. Importantly, adipocyte-specific gp knockout mice were protected from high fat diet HFD -induced hepatic steatosis as well as insulin resistance. WueestF.

Our results demonstrate that IL-6 cytokine-induced lipolysis may be restricted to mesenteric WAT and that it contributes to hepatic insulin resistance and steatosis. The terms and their relations were extracted from ZORA using word statistics. Adipose tissue inflammation contributes to short-term high-fat diet-induced hepatic insulin resistance.

Abstract Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and are tightly associated with obesity and type 2 diabetes. Importantly, adipocyte-specific gp knockout mice were protected from high fat diet HFD -induced hepatic steatosis as well as insulin resistance. Publisher 'American Diabetes Association'. Our results demonstrate that IL-6 cytokine-induced lipolysis may be restricted to mesenteric WAT and that it contributes to hepatic insulin resistance and steatosis. Of note, adipocyte-specific gp knockout mice were protected from high-fat diet-induced hepatic steatosis as well as from insulin resistance. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. The results show that IL-6 cytokine-induced lipolysis may be restricted to mesenteric white adipose tissue and that it contributes to hepatic insulin resistance and steatosis.

Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and are tightly ressitance with obesity and type 2 diabetes. Glycoprotein gp is the common signal transducer of all interleukin 6 IL-6 cytokines. I agree, dismiss this banner. JavaScript is required to view the contents of this page. We provide evidence that gpmediated adipose tissue lipolysis promotes hepatic steatosis and insulin resistance.

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