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Anti obesity medicinal plants: Dietary Patterns for the Reduction of Obesity Using Medicinal Plants in Northern Pakistan

In our present review, we differentiated the anti-obesogenic effects of various medicinal plant extracts, fractions and their bioactive compounds at in vitro, in vivo and clinical conditions.

William Murphy
Wednesday, August 22, 2018
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  • Kuriyan, T. Al-Shafie' et al.

  • Abstract Obesity is the most prevalent health problem affecting all age groups, and leads to many complications in the form of chronic heart disease, diabetes mellitus Type 2 and stroke.

  • Da-Huang is derived from the dried root and rhizome of Rheum palmatum L.

  • It suppresses the expression of SREBP-1 as well as that of fatty acid synthase in adipose and liver tissues. Azadirachta indica A.

MeSH terms

Obesity is the most prevalent health problem affecting all age groups, and leads to many complications in the form of chronic heart disease, diabetes mellitus Type 2 and stroke. Abstract Ethnopharmacological relevance: As an effort to identify newer anti-obesity lead s we have selected 13 plant materials from the six plant species which have been reported in Indian Ayurvedic medicine as remedy against complications affecting glucose and lipid homeostasis. No other significant adverse effects were reported in all 33 trials included in this article. Given these findings, ethnopharmacological approaches are relevant scientific tools in the selection of plant species for studies that demonstrate anti-obesity action.

We analyzed and organized data on 76 plant angi, cataloged per the taxonomy, geographic distribution, botanical aspects, popular use, and chemical and biological studies of the listed plants. Substances Anti-Obesity Agents. Further, three bioactive flavonoids were medicinal plants and identified as oroxylin A, chrysin and baicalein from O. Publication types Review Systematic Review. Inhibition of lipid accumulation and adipogenic transcription factor was measured by oil Red 'O' staining and quantitative real-time PCR method respectively. In contrast, plant based drugs have been considered as a better alternative due to their lower cost and negligible side effects. Results: Ethyl acetate extract of Oroxylum indicum bark was found to be most active in screening of anti-adipogenesis

Xu, H. Abstract We evaluated the antioxidant and porcine pancreatic lipase inhibition PPLI activities of 90 plants extracts. Obesity Silver Spring ; 18 — Moraceae Mulberry FR Toot Obesity accompanied by hyperlipidemia which is indicated by abnormally high concentration of lipids in blood [ 7 ]. Current Clin Pharmacol 4: It reduces weight gain, white adipose tissue mass, and serum triglyceride and cholesterol levels.

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The antiobesity effects such as body weight reduction, decrease in the levels of triglycerides, total cholesterol, and low density lipoprotein cholesterol with simultaneous increase in high density lipoprotein cholesterol was observed in the animals treated with the plants [ 11529313954607879838598,,]. Effect of supplementation of traditional medicinal plants on blood glucose in non-insulin-dependent diabetics: A pilot study. High-fat dietinduced obese mice [] 91 Populus balsamifera L.

Further, three bioactive flavonoids were isolated and identified as oroxylin A, chrysin and baicalein from O. Substances Anti-Obesity Agents. One of the alternatives in the treatment of obesity is the traditional use of medicinal plants, which supports the research and development of obesity phytotherapy. Abstract Ethnopharmacological relevance: As an effort to identify newer anti-obesity lead s we have selected 13 plant materials from the six plant species which have been reported in Indian Ayurvedic medicine as remedy against complications affecting glucose and lipid homeostasis. The effect size of these medicinal plants is a critical point that should be considered for interpretation.

Fruits were commonly anti obesity medicinal plants plant part and extract was the common mode for herbal preparations while oral intake was the common route of administration. Home Publications Conferences Register Contact. Download other formats More. El-Shemy, Ed. Ma et al. Obesity, being a prominent syndrome in Pakistani society but up till there is no existing ethnobotanical surveys on medicinal plants used for this purpose so the present work in the first step towards this direction. Elzaawely, T.

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Figure 7: Other diseases related to obesity and overweight in the study area. Ikramuddin, J. Guidelines Upcoming Special Issues. To the fresh leaves extract China berry soft stem juice and powder of Nigella sativa seeds are properly mixed. The dried leaves of this plant are slightly crushed.

Numerous studies have indicated that these plants are potential candidates for the prevention and management of anyi. The anti-obesity effect of the cataloged species anti obesity medicinal plants reported, describing actions on the delay of fat absorption, suppression of enzymatic activities, mediation of lipid levels and increase of lipolytic effects, attributed mainly to phenolic compounds. All rights reserved. It is closely associated with the occurrence of several chronic diseases, such as diabetes and cardiovascular diseases.

This change in the metabolism in the adipocytes is regulated by various enzymes such as fatty acid synthase, lipoprotein lipase and adipocyte fatty anti obesity medicinal plants protein [ 3 ]. Use of herbal medicine to treat obesity is currently garnering much attention. Jarocka-Cyrta, and M. Yue Liu. Leguminosae Fruit pulp,pulp, seed coat Levelsof plasma total cholesterol, lowdensity lipoprotein, andtriglyceride is decreased and it increases high-density lipoprotein, with the concomitant reduction of body weight.

Obesity is a global epidemic that has shown a steady increase in morbimortality indicators; it is considered a social problem and entails serious health risks. Obesity is the most prevalent health problem affecting all age groups, and leads to many complications in the form of chronic heart disease, diabetes mellitus Type 2 and stroke. All rights reserved. The anti-obesity effect of the cataloged species was reported, describing actions on the delay of fat absorption, suppression of enzymatic activities, mediation of lipid levels and increase of lipolytic effects, attributed mainly to phenolic compounds. Ethnopharmacological relevance: As an effort to identify newer anti-obesity lead s we have selected 13 plant materials from the six plant species which have been reported in Indian Ayurvedic medicine as remedy against complications affecting glucose and lipid homeostasis. Further, three bioactive flavonoids were isolated and identified as oroxylin A, chrysin and baicalein from O.

Publication types

Abstract In recent years, obesity has become a global public health issue. Human mortality has been significantly increased in last few decades due anti obesity medicinal plants the oesity prevalence of obesity and associated chronic disorders such as type 2 diabetes, non-alcoholic fatty liver disease, coronary heart disease and atherosclerosis. Publication types Review. Keywords: Weight loss; anti-obesity medicines; reduction diet. In contrast, plant based drugs have been considered as a better alternative due to their lower cost and negligible side effects.

  • Antiobesity mechanisms and related beneficial effects of Mentha spicata extracts and their bioactive constituents. It increases glucose tolerance and reduced plasma triglycerides level.

  • Actually we limited our search to such a narrow window of time in order to update our article published before December of

  • Take cups daily for a month. Prunus dulcis Mill.

  • High fat diet- induced mice, 6-week-old male hamsters. Punicaceae Pomegranate HS Rumman

Keywords: Weight loss; anti-obesity medicines; reduction diet. In our present review, we differentiated the anti-obesogenic effects of various medicinal plant extracts, fractions and their bioactive compounds at in vitro, in vivo and clinical conditions. Substances Anti-Obesity Agents. Abstract Obesity is the most prevalent health problem affecting all age groups, and leads to many complications in the form of chronic heart disease, diabetes mellitus Type 2 and stroke. Publication types Review. Obesity is a global epidemic that has shown a steady increase in morbimortality indicators; it is considered a social problem and entails serious health risks.

  • Conde, B. The uses of natural products for treating obesity are under exploration, which is an alternative way for developing safe anti-obesity drugs [ 57 - 59 ].

  • Inhibition of lipid accumulation anti obesity medicinal plants adipogenic transcription factor was measured by oil Red 'O' staining and quantitative real-time PCR method respectively. Human mortality has been significantly increased in last few decades due to the increased prevalence of obesity and associated chronic disorders such as type 2 diabetes, non-alcoholic fatty liver disease, coronary heart disease and atherosclerosis.

  • Brahmi, D. S—S,

  • A number of medicinal plants and their bioactive constituents have received attention from scientists not only for their anti-obesity activity in vitro and in vivo but also in clinical trials.

  • References Y.

  • Free radicals are involved in many disorders like cancer, diabetes mellitus, and neurodegenerative and inflammatory diseases.

Substances Anti-Obesity Agents Phytochemicals. Abstract Anti obesity medicinal mortality has been significantly increased in last few decades due to the increased prevalence of mediinal and associated chronic disorders such as type 2 diabetes, non-alcoholic fatty liver disease, coronary heart disease and atherosclerosis. In this article, we provide information about ethnopharmacological species used to treat obeslty, through an electronic search of the periodical databases Web of ScienceScopusPubMed and Scieloconsidering the period and using the descriptors "plants for obesity", "ethnopharmacology for obesity" and "anti-obesity plants" in both Portuguese and English. In our present review, we differentiated the anti-obesogenic effects of various medicinal plant extracts, fractions and their bioactive compounds at in vitro, in vivo and clinical conditions. Only, alginate-based brown seaweed and Laminaria Digitata caused an abdominal bloating and upper respiratory tract infection as the side effect in the trial group. Conclusion: The present study augurs the anti-obesity potential of well practiced Ayurvedic herb O. In this review, the anti-obesity activity of edible and medicinal plants was summarized based on epidemiological, experimental, and clinical studies, with related mechanisms discussed, which provided the basis for the research and development of slimming products.

Publication types Review. Obesity is the most prevalent health problem affecting all age ;lants, and leads to many complications in the form of chronic heart disease, diabetes mellitus Type 2 and stroke. The anti-obesity effect of the cataloged species was reported, describing actions on the delay of fat absorption, suppression of enzymatic activities, mediation of lipid levels and increase of lipolytic effects, attributed mainly to phenolic compounds. Abstract Obesity is the most prevalent health problem affecting all age groups, and leads to many complications in the form of chronic heart disease, diabetes mellitus Type 2 and stroke. It is closely associated with the occurrence of several chronic diseases, such as diabetes and cardiovascular diseases. A number of medicinal plants and their bioactive constituents have received attention from scientists not only for their anti-obesity activity in vitro and in vivo but also in clinical trials.

Open Access Journals

Viner, Y. Reduces animal body weights of the fat in white adipose tissues, glucose, total cholesterol, triglycerides, and LDL-c and insulin blood levels. Citrus paradisi Macfad. Singh, M. NCT unknown.

The major anti-obesity mechanisms of plants include suppressing appetite, reducing the absorption of lipids and carbohydrates, inhibiting adipogenesis and lipogenesis, regulating lipid metabolism, increasing energy expenditure, regulating gut microbiota, and improving obesity-related inflammation. Total number of publications for review study was 33 by excluding publications related to animals study. The effect size of these medicinal plants is a critical point that should be considered for interpretation. In this article, we provide information about ethnopharmacological species used to treat obesity, through an electronic search of the periodical databases Web of ScienceScopusPubMed and Scieloconsidering the period and using the descriptors "plants for obesity", "ethnopharmacology for obesity" and "anti-obesity plants" in both Portuguese and English. However, there is no systematic review of data available in the scientific domain in order to guide researchers to conduct further in depth research. Substances Anti-Obesity Agents. Obesity is a global epidemic that has shown a steady increase in morbimortality indicators; it is considered a social problem and entails serious health risks.

In our present review, we differentiated the anti-obesogenic effects of medicinal plants medicinal plant extracts, fractions and their bioactive compounds at in vitro, in vivo and clinical conditions. Oroxylin A, chrysin, and baicalein were inhibited lipid accumulation in 3T3-L1 preadipocytes Substances Anti-Obesity Agents Phytochemicals. Anfi number of medicinal plants and their bioactive constituents have received attention from scientists not only for their anti-obesity activity in vitro and in vivo but also in clinical trials. Human mortality has been significantly increased in last few decades due to the increased prevalence of obesity and associated chronic disorders such as type 2 diabetes, non-alcoholic fatty liver disease, coronary heart disease and atherosclerosis. Keywords: Anti-obesity; appetite; energy expenditure; mechanisms; plants. Materials and methods: In vitro anti-adipogenic assay using 3T3-L1 preadipocytes and pancreatic lipase PL inhibition assay were performed for hexanes, dichloromethane, ethyl acetate and methanolic extracts of all the plant materials.

Rosaceae Apple FR i Add one teaspoon of apple vinegar to a glass of water; drink 3 times daily after meals. Xie, D. Ng, T. The RP was evaluated by measuring absorbance at nm after mixing the samples with ferric compounds; higher absorbance indicates higher RP.

Evidence-Based Complementary and Alternative Medicine

In contrast, plant based drugs have been considered as a better alternative due to their lower cost and negligible side effects. Obesity is the most prevalent health problem medicinal plants all age groups, and leads to many complications in the form of chronic heart disease, diabetes mellitus Type 2 and stroke. Actually we limited our search to such a narrow window of time in order to update our article published before December of In this review, the anti-obesity activity of edible and medicinal plants was summarized based on epidemiological, experimental, and clinical studies, with related mechanisms discussed, which provided the basis for the research and development of slimming products.

  • To the leaves extract of this plant add some water and strain it. Apiaceae Cumin SD i Mix equal amounts of the seeds of cumin, fennel, anise, and senna leaves; eat one teaspoon daily after lunch.

  • Keywords: Anti-obesity; appetite; energy expenditure; mechanisms; plants. Substances Anti-Obesity Agents.

  • Zhu, X. Reduces animal body weights of the fat in white adipose tissues, glucose, total cholesterol, triglycerides, and LDL-c and insulin blood levels.

  • Kim et al. Lipids Health Dis.

Obesity is the most prevalent health problem affecting all age groups, and leads to many complications in the form of chronic heart disease, diabetes antk Type 2 and stroke. During our review, we could also identify the most effective plants with strong anti-obesogenic effects at in vitro or in vivo studies with lack of clinical trials when no one tried to isolate pure bioactive compounds from these plants. In our present review, we differentiated the anti-obesogenic effects of various medicinal plant extracts, fractions and their bioactive compounds at in vitro, in vivo and clinical conditions. Conclusion: The present study augurs the anti-obesity potential of well practiced Ayurvedic herb O.

No other anti obesity medicinal plants adverse effects were reported in all 33 trials included in this article. Abstract In recent years, obesity has become a global public health issue. A systematic review about safety and efficacy of herbal medicines in the management of obesity in human was carried out by searching bibliographic data bases such as, PubMed, Scopus, Google Scholar, Web of Science, and IranMedex, for studies reported between 30th December to 23rd April on human or animals, investigating the beneficial and harmful effects of herbal medicine to treat obesity. In recent years, obesity has become a global public health issue. Substances Anti-Obesity Agents. Publication types Review.

  • Wang, R.

  • Deeper botanical, chemical, pre-clinical and clinical studies are particularly necessary for species that present phenolic compounds in their chemical structure.

  • The scenario becomes more complicated due to various environmental, medical, socioeconomic, nutritional, genetically causative factors and lack of data regarding its prevalence.

  • Yaniv, A. Pure pancreatic lipase [54,].

  • Hosein, S.

The ability of the plant extracts to inhibit PPL was measured using the modified anti obesity medicinal plants previously reported by Bustanji et al. Rubiaceae Seed C. Solanum melongena L. Koh et al. There was considerable age wise difference in knowledge of individuals and its vertical transfer was getting slow. Rui Gao and Yue Liu contributed to the topic conception, manuscript revision, and the decision to submit for publication and are the co-corresponding authors.

The study published by Hoo et al. Atamna, F. Phyllanthus emblica L. Address for correspondence: Mr. Higdon JV, Frei B Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. The main active component of Carthamus tinctorius L. Scientific World J.

REFERENCES

Abstract Obesity is the most prevalent health problem affecting all age groups, and leads to many complications in the form of chronic heart disease, diabetes mellitus Type 2 and stroke. It is closely associated with the occurrence of several chronic diseases, such as diabetes and cardiovascular diseases. Total number of publications for review study was 33 by excluding publications related to animals study. Obesity is the most prevalent health problem affecting all age groups, and leads to many complications in the form of chronic heart disease, diabetes mellitus Type 2 and stroke. Abstract Ethnopharmacological relevance: As an effort to identify newer anti-obesity lead s we have selected 13 plant materials from the six plant species which have been reported in Indian Ayurvedic medicine as remedy against complications affecting glucose and lipid homeostasis.

Food Technol Biotechnol —16 Google Scholar. The results indicate that Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota, reducing endotoxemia, and preventing medkcinal resistance. Dysregulated metabolism that stems from obesity including insulin resistance, hyperglycemia, and dyslipidemia can further affect tumor growth and development. Yang et al. In this scrupulous survey, 77 medicinal plant species from 38 families were documented for the treatment and prevention of obesity Table 2. The active compounds umbelliferone and esculetin from the plant Aegle marmelos have shown marked effect by depleting the lipid content in the adipocytes and by decreasing the hyperlipidemia.

Further studies should focus on the exploration obessity safer plants with anti-obesity activity and the identification of specific anti-obesity mechanisms. Deeper botanical, chemical, pre-clinical and anti obesity medicinal plants studies are particularly necessary for species that present phenolic compounds in their chemical structure. Keywords: Weight loss; anti-obesity medicines; reduction diet. Some edible and medicinal plants show anti-obesity activity, such as fruits, vegetables, spices, legumes, edible flowers, mushrooms, and medicinal plants. Publication types Review. Obesity is the most prevalent health problem affecting all age groups, and leads to many complications in the form of chronic heart disease, diabetes mellitus Type 2 and stroke.

Fabaceae Fenugreek SD i A decoction is prepared from 1 teaspoon of the seeds in ml of water; take cups daily. Zhou, X. Kim, K.

Publications with abstract from the mentioned databases were used to prepare this review. Hum Exp Toxicol. Hudifa, A. To the soft stem and leaves juice in water of this plant, add emblic seeds powder and black chili seeds powder. Liu, L. According to the recent WHO report, more than 1. Antioxidants due to their scavenging activity are useful for the management of those diseases [ 5455 ].

In contrast, plant based drugs have been considered as a better alternative due to their lower cost and negligible side effects. The anti-obesity effect of the cataloged species was reported, describing actions on the delay of fat absorption, suppression of enzymatic activities, mediation of lipid levels and increase of lipolytic effects, attributed mainly to phenolic compounds. During our review, we could also identify the most effective plants with strong anti-obesogenic effects at in vitro or in vivo studies with lack of clinical trials when no one tried to isolate pure bioactive compounds from these plants. Obesity is the most prevalent health problem affecting all age groups, and leads to many complications in the form of chronic heart disease, diabetes mellitus Type 2 and stroke. Deeper botanical, chemical, pre-clinical and clinical studies are particularly necessary for species that present phenolic compounds in their chemical structure. Substances Anti-Obesity Agents. Publication types Review Systematic Review.

Results: Ethyl acetate extract of Oroxylum indicum bark was found to be most active in screening of anti-adipogenesis Ogesity we limited our search to such a narrow window of time in order to update our article published before December of Total number of publications for review study was 33 by excluding publications related to animals study. Total publications found in the initial search were Substances Anti-Obesity Agents Phytochemicals.

Aim of the study: In vitro screening of six Indian Ayurvedic medicinal plants on anti-adipogenic and pancreatic lipase PL inhibition potential followed by bioactivity guided isolation from most active plant material. The effect size of these medicinal plants is a critical point that should be considered for interpretation. In this review, the anti-obesity activity of edible and medicinal plants was summarized based on epidemiological, experimental, and clinical studies, with related mechanisms discussed, which provided the basis for the research and development of slimming products. In this update, the search terms were "obesity" and "herbal medicine" or "plant", "plant medicinal" or "medicine traditional" without narrowing or limiting search items. In contrast, plant based drugs have been considered as a better alternative due to their lower cost and negligible side effects. Inhibition of lipid accumulation and adipogenic transcription factor was measured by oil Red 'O' staining and quantitative real-time PCR method respectively.

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Publications with available abstracts were reviewed only. The anti-obesity effect of the cataloged species was reported, describing actions on the delay of fat absorption, suppression of enzymatic activities, mediation of lipid levels and increase of lipolytic effects, attributed mainly to phenolic compounds. Some edible and medicinal plants show anti-obesity activity, such as fruits, vegetables, spices, legumes, edible flowers, mushrooms, and medicinal plants. Publication types Review Systematic Review. No other significant adverse effects were reported in all 33 trials included in this article.

Publication types Review Systematic Review. A systematic review about safety and efficacy of herbal medicines in the management of obesity in human was carried out by searching bibliographic data bases such as, PubMed, Scopus, Google Scholar, Web of Science, and IranMedex, for anti obesity medicinal plants reported between 30th December to 23rd April on human or animals, investigating the beneficial and harmful effects of herbal medicine to treat obesity. Deeper botanical, chemical, pre-clinical and clinical studies are particularly necessary for species that present phenolic compounds in their chemical structure. The major anti-obesity mechanisms of plants include suppressing appetite, reducing the absorption of lipids and carbohydrates, inhibiting adipogenesis and lipogenesis, regulating lipid metabolism, increasing energy expenditure, regulating gut microbiota, and improving obesity-related inflammation. Some edible and medicinal plants show anti-obesity activity, such as fruits, vegetables, spices, legumes, edible flowers, mushrooms, and medicinal plants.

Inhibition of lipid accumulation and adipogenic transcription factor was measured by oil Red 'O' staining and quantitative real-time PCR method respectively. In boesity review, the anti-obesity activity of edible and medicinal plants was summarized based on epidemiological, experimental, and clinical studies, with related mechanisms discussed, which provided the basis for the research and development of slimming products. Abstract Ethnopharmacological relevance: As an effort to identify newer anti-obesity lead s we have selected 13 plant materials from the six plant species which have been reported in Indian Ayurvedic medicine as remedy against complications affecting glucose and lipid homeostasis.

  • Chen, L. To evaluate the effectiveness and safety of the empirical formula—Xiere Huazhuo Formula of Chinese Medicine Professor—Ding Xueping in obesity treatment.

  • Obesity meicinal a global epidemic that has shown a steady increase in morbimortality indicators; it is considered a social problem and entails serious health risks. We analyzed and organized data on 76 plant species, cataloged per the taxonomy, geographic distribution, botanical aspects, popular use, and chemical and biological studies of the listed plants.

  • Leguminosae Bean It inhibits adipocyte differentiation in 3T3-L1 preadipocyte cells. Therefore, for treating obesity they have been widely used [ 60 ].

  • Aim of the study: In vitro screening of six Indian Ayurvedic medicinal plants on anti-adipogenic and pancreatic lipase PL inhibition potential followed by bioactivity guided isolation from most active plant material. Publication types Review.

Human mortality has been significantly increased in last few decades due to medicinal plants increased prevalence of obesity and associated chronic disorders such as type 2 diabetes, non-alcoholic fatty liver disease, coronary heart disease and atherosclerosis. Publication types Review. Abstract Human mortality has been significantly increased in last few decades due to the increased prevalence of obesity and associated chronic disorders such as type 2 diabetes, non-alcoholic fatty liver disease, coronary heart disease and atherosclerosis. Publication types Review. Substances Anti-Obesity Agents.

Tolan, E. Ojcius, C. Richter et al. The presence of ephedrine and pseudoephedrine in the plant Sida rhomboidea induced appetite suppression that inhibits body weight gain. Ash, and G.

Calotropis procera Aiton Dryand. To examine the treatment of adiposity stagnation of QI causing phlegm retention. Syzygium cumini L. Atkinson RL Current status of the field of obesity. Recommended Journals.

Active compounds umbelliferone and esculetin depletes lipid content in anti obesity medicinal plants adipocytes and by decreasing the hyperlipidemia in obese rats fed with high-fat diet. Scientific World J. Pongamia pinnata L. The antiobesity effects such as body weight reduction, decrease in the levels of triglycerides, total cholesterol, and low density lipoprotein cholesterol with simultaneous increase in high density lipoprotein cholesterol was observed in the animals treated with the plants [ 11529313954607879838598,,].

Chen, L. Also, warm them in non-stick pan for 5 mints. Advertisement Hide. Xanthorrhoeaceae Aloe LE Sabrah murrah

  • Passifloraceae Leaves The herbal preparation capsules delays gastric emptying, reducing the time to perceived gastric fullness and induces weight loss. Cordell, and I.

  • A systematic review about safety and efficacy of herbal medicines in the management of plantx in human was carried out by searching bibliographic data bases such as, PubMed, Scopus, Google Scholar, Web of Science, and IranMedex, for studies reported between 30th December to 23rd April on human or animals, investigating the beneficial and harmful effects of herbal medicine to treat obesity.

  • Pancreatic lipase plays a key role in the efficient digestion of triglycerides [ 20 ].

  • Total number of publications for review study was 33 by excluding publications related to animals study. Substances Anti-Obesity Agents.

  • The anti-obesity effect of the cataloged species was reported, describing actions on the delay of fat absorption, suppression of enzymatic activities, mediation of lipid levels and increase of lipolytic effects, attributed mainly to phenolic compounds.

Materials and methods: In vitro anti-adipogenic assay using 3T3-L1 preadipocytes and pancreatic lipase PL inhibition assay were performed for hexanes, dichloromethane, ethyl acetate and methanolic extracts of all the plant materials. In our present review, we differentiated the anti-obesogenic effects of various medicinal plant extracts, fractions and their bioactive compounds at in vitro, in vivo and clinical conditions. Publication types Review Systematic Review. Publication types Review. Further, three bioactive flavonoids were isolated and identified as oroxylin A, chrysin and baicalein from O.

Prasanna M. Article Usage. Smith A Effect of aqueous extract of Senna siamea Cassia leaves on the liver and kidney of albino rats. Anti-obesity effect of A. Phytomedicine: An ancient approach turning into future potential source of therapeutics.

Abstract Ethnopharmacological relevance: As medicinal plants effort to identify newer anti-obesity lead s we have selected 13 plant materials from the six plant species obrsity have been reported in Indian Ayurvedic medicine as remedy against complications affecting glucose and lipid homeostasis. Results: Ethyl acetate extract of Oroxylum indicum bark was found to be most active in screening of anti-adipogenesis Total publications found in the initial search were Actually we limited our search to such a narrow window of time in order to update our article published before December of No other significant adverse effects were reported in all 33 trials included in this article.

Abstract In recent years, obesity has become a global public health issue. Further, three bioactive flavonoids were isolated and identified as oroxylin A, chrysin and baicalein from O. Given these findings, ethnopharmacological approaches are relevant scientific tools in the selection of plant species for studies that demonstrate anti-obesity action. Materials and methods: In vitro anti-adipogenic assay using 3T3-L1 preadipocytes and pancreatic lipase PL inhibition assay were performed for hexanes, dichloromethane, ethyl acetate and methanolic extracts of all the plant materials.

Total number of publications for review study was 33 by excluding publications related to animals study. Only, alginate-based brown medicinal plants and Laminaria Digitata caused an abdominal bloating and upper respiratory tract infection as the side effect in the trial group. In recent years, obesity has become a global public health issue. Total publications found in the initial search were Further studies should focus on the exploration of safer plants with anti-obesity activity and the identification of specific anti-obesity mechanisms.

We plants and organized data on 76 plant species, cataloged per the taxonomy, mmedicinal distribution, botanical aspects, popular use, and chemical and biological studies of the listed plants. Total number of publications for review study was 33 by excluding publications related to animals study. Oroxylin A, chrysin, and baicalein were inhibited lipid accumulation in 3T3-L1 preadipocytes Some edible and medicinal plants show anti-obesity activity, such as fruits, vegetables, spices, legumes, edible flowers, mushrooms, and medicinal plants.

During our review, we could also identify the most effective plants with strong anti-obesogenic plans at in vitro or in vivo studies with lack of clinical trials when no medicinal plants tried to isolate pure bioactive compounds from these plants. Publication types Review. Total publications found in the initial search were Publications with available abstracts were reviewed only. Bioactivity guided isolation approach was used to identify active constituent for anti-adipogenesis and PL inhibition assay. Results: Ethyl acetate extract of Oroxylum indicum bark was found to be most active in screening of anti-adipogenesis Publication types Review Systematic Review.

Actually we limited our search to such a narrow window of time in order to update our article published before December of In this update, the search plants were "obesity" and "herbal medicine" or "plant", "plant medicinal" or "medicine traditional" without narrowing or limiting search items. In recent years, obesity has become a global public health issue. Aim of the study: In vitro screening of six Indian Ayurvedic medicinal plants on anti-adipogenic and pancreatic lipase PL inhibition potential followed by bioactivity guided isolation from most active plant material.

Actually we limited our search to such a narrow window of time in order to update our article published before December of A number of medicinal plants and their bioactive constituents have received attention from scientists not only for their anti-obesity activity in vitro and in vivo but also in clinical trials. Further studies should focus on the exploration of safer plants with anti-obesity activity and the identification of specific anti-obesity mechanisms.

Arumugam, N. Published 13 Jun The leaves and epicarp of Rhus coriaria exhibited the highest antioxidant activity in both assays. Evidence based herbal drug standardization approach in coping with challenges of holistic management of diabetes: A dreadful lifestyle disorder of 21 st century.

El-Khateeb, and K. It reduces weight gain, white adipose tissue mass, and serum triglyceride and cholesterol levels. Shanak, and S. The seed oil of this plant is recommended to take half an hour before meal, as it reduces hunger.

Ryu, S. Citrus paradisi Macfad. Take 3 cups daily.

Huang qi is derived from the dried root of Astragalus membranaceus Fisch. Yamamura, K. Trigonella foenum-graecum L. Human clinical trials [] 2 Cissus quadrangularis L. Yaniv, and D. Mentha arvensis L.

Figure 5: Plant plants used in treatment of obesity. The fresh leaves extract after adding some water is strained through soft batiste cloth. Marsh, S. Apiaceae Anise SD i Mix equal amounts of the seeds of anise, cumin, fennel, and senna; eat one teaspoon daily after lunch. Kimura et al. Serumlevelsof total cholesterol and triacylglycerols are decreased but high-density lipoprotein cholesterol increased.

Soukontoua, and G. Eleven studies [ 16 — 182021232528 — 30 anti obesity medicinal plants, 33 ] mentioned complications, including hypertension, impaired glucose tolerance, spleen hypofunction, excessive sweating, nonalcoholic fatty liver disease, hyperlipidemia, and metabolic syndrome. Eight plant extracts which show strong PPL inhibitory activity have shown possessing weak antioxidant activity by both methods. Hezhi Yao contributed to references analysis and helped in revising manuscript.

  • Nowadays, changes in human lifestyle and high energy diet have increased the incidence of obesity and even have become a risk factor to the population of children [ 1112 ]. Faridullah, S.

  • In this review, the anti-obesity activity of edible and medicinal plants was summarized based on epidemiological, experimental, and clinical studies, with related mechanisms discussed, which provided the basis for the research and development of slimming products. Aim of the study: In vitro screening of six Indian Ayurvedic medicinal plants on anti-adipogenic and pancreatic lipase PL inhibition potential followed by bioactivity guided isolation from most active plant material.

  • Teucrium capitatum L.

  • This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Given these findings, ethnopharmacological approaches are relevant scientific tools in the selection of plant species for plants that demonstrate anti-obesity action. In our present review, we differentiated obeslty anti-obesogenic effects of various medicinal plant extracts, fractions and their bioactive compounds at in vitro, in vivo and clinical conditions. Deeper botanical, chemical, pre-clinical and clinical studies are particularly necessary for species that present phenolic compounds in their chemical structure. One of the alternatives in the treatment of obesity is the traditional use of medicinal plants, which supports the research and development of obesity phytotherapy.

Pllants 4 presents the top 5 plant extracts in comparison with orlistat as plants control. Select your language of interest to view the total content in your interested language. Chen, and Z. Apiaceae Anise SD i Mix equal amounts of the seeds of anise, cumin, fennel, and senna; eat one teaspoon daily after lunch. Plant derived products may also contain phytochemicals that act as enzyme inhibitors [ 33 ].

The dominant families regarding number of species were Fabaceae 10 spp. Cherniack EP Potential applications for alternative medicine to treat obesity in an aging population. Alias, T. Wen, Y. Aqueous extract of P.

Materials and methods: In vitro anti-adipogenic assay using 3T3-L1 preadipocytes and pancreatic lipase PL inhibition assay were plants for hexanes, dichloromethane, ethyl acetate and methanolic extracts of all the plant materials. In recent years, obesity has become a global public health issue. Results: Ethyl acetate extract of Oroxylum indicum bark was found to be most active in screening of anti-adipogenesis

Substances Anti-Obesity Agents. Numerous studies have indicated that these plants are potential candidates for plants prevention and management of obesity. Deeper botanical, chemical, pre-clinical and clinical studies are particularly necessary for species that present phenolic compounds in their chemical structure. Keywords: Weight loss; anti-obesity medicines; reduction diet. A number of medicinal plants and their bioactive constituents have received attention from scientists not only for their anti-obesity activity in vitro and in vivo but also in clinical trials. Actually we limited our search to such a narrow window of time in order to update our article published before December of

Although there was no report for side effect in these trials, we believe that safety of these plants still remains to be elucidated by further long-term studies. In contrast, plant based drugs have been considered as a better alternative due to their lower cost and negligible side effects. No other significant adverse effects were reported in all 33 trials included in this article. Results: Ethyl acetate extract of Oroxylum indicum bark was found to be most active in screening of anti-adipogenesis Publication types Review. Keywords: Weight loss; anti-obesity medicines; reduction diet. The effect size of these medicinal plants is a critical point that should be considered for interpretation.

Dietary and traditional behavioral treatments of obesity are current conventional methods medicunal medicinal plants in long-term management. Deng et al. Use of herbal medicine to treat obesity is currently garnering much attention. To the fruit vinegar of this plant are added 1 teaspoon honey and lemon juice, each. It potently induces mitochondrial activity by activating thermogenesis and improving endurance capacity and also inhibited adipogenic factors in vitro. Saad B Greco-Arab and islamic herbal medicine, a review.

Xin-ju-xiao-gao-fang rhubarb, Coptissemen cassia, Citrus aurantium. Elzaawely, T. Jeon, M. The adipose tissue, an plantw organ, has a major role in the regulation of metabolism and homeostasis, through the secretion of several biologically active adipokines [ 8 ]. Phytomedicine: An ancient approach turning into future potential source of therapeutics.

Extract of A. Medicknal, the use of naturally occurring inhibitors is considered to be safer [ 19 ]. Shen Y, Song SJ, Keum N, Park T Olive leaf extract attenuates obesity in high-fat diet-fed mice by modulating the expression of molecules involved in adipogenesis and thermogenesis. Stene et al. Chang et al.

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Obesity is a global epidemic that has shown a steady increase in morbimortality indicators; it is considered a social problem and entails serious health risks. However, there is no systematic review of data available in the scientific domain in order to guide researchers to conduct further in depth research. Bioactivity guided isolation approach was used to identify active constituent for anti-adipogenesis and PL inhibition assay. Human mortality has been significantly increased in last few decades due to the increased prevalence of obesity and associated chronic disorders such as type 2 diabetes, non-alcoholic fatty liver disease, coronary heart disease and atherosclerosis. Oroxylin A, chrysin, and baicalein were inhibited lipid accumulation in 3T3-L1 preadipocytes Further, three bioactive flavonoids were isolated and identified as oroxylin A, chrysin and baicalein from O.

No other anti obesity adverse effects were reported in all 33 trials included in this article. A systematic review about safety and efficacy of herbal medicines in the management of obesity in human was carried out by searching bibliographic data bases such as, PubMed, Scopus, Google Scholar, Web of Science, and IranMedex, for studies reported between 30th December to 23rd April on human or animals, investigating the beneficial and harmful effects of herbal medicine to treat obesity. Deeper botanical, chemical, pre-clinical and clinical studies are particularly necessary for species that present phenolic compounds in their chemical structure. However, there is no systematic review of data available in the scientific domain in order to guide researchers to conduct further in depth research. Inhibition of lipid accumulation and adipogenic transcription factor was measured by oil Red 'O' staining and quantitative real-time PCR method respectively. Obesity is a global epidemic that has shown a steady increase in morbimortality indicators; it is considered a social problem and entails serious health risks. Aim of the study: In vitro screening of six Indian Ayurvedic medicinal plants on anti-adipogenic and pancreatic lipase PL inhibition potential followed by bioactivity guided isolation from most active plant material.

  • Koh et al. This study provides us the recognition and documentation of anti-obesity plants knowledge which could further be exploited by phytochemical investigations that may lead to isolation and characterization of new possible novel agents.

  • Publication types Review. Obesity is a global epidemic that has shown a steady increase in morbimortality indicators; it is considered a social problem and entails serious health risks.

  • The lipase activity was determined by measuring the hydrolysis of p-nitrophenol butyrate pNPB to p-nitrophenol at nm using UV-VIS spectrophotometer. Z of Dr.

  • Aim of the study: In vitro screening of six Indian Ayurvedic medicinal plants on anti-adipogenic and pancreatic lipase PL inhibition potential followed by bioactivity guided isolation from most active plant material.

  • In this review, the anti-obesity activity of edible and medicinal plants was summarized based on epidemiological, experimental, and clinical studies, with related mechanisms discussed, which provided the basis for the research and development of slimming products. In recent years, obesity has become a global public health issue.

It also decreases insulin level. That is the reason for annti withdrawal from the market of some older drugs such as Sibutral, rimonabant, isomeride, ponderal, and Xenical [ anti obesity medicinal18 ]. Saadi, S. Thus, it is preferred to assess the antioxidant capacity of a plant extract by more than one method, as different methods can assess scavenging capacity of different free radicals and this can explain the difference in the antioxidant activity of the tested plant extracts using DPPH and RP assays. Apiaceae Anise SD i Mix equal amounts of the seeds of anise, cumin, fennel, and senna; eat one teaspoon daily after lunch.

Total number of publications for review study was 33 by excluding publications related to animals study. Abstract Ethnopharmacological relevance: As planrs effort to identify newer anti-obesity lead s we have selected 13 anti obesity medicinal plants materials from the six plant species which have been reported in Indian Ayurvedic medicine as remedy against complications affecting glucose and lipid homeostasis. No other significant adverse effects were reported in all 33 trials included in this article. Materials and methods: In vitro anti-adipogenic assay using 3T3-L1 preadipocytes and pancreatic lipase PL inhibition assay were performed for hexanes, dichloromethane, ethyl acetate and methanolic extracts of all the plant materials.

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