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Amy1 obesity surgery – Low Copy Number of the AMY1 Locus Is Associated with Early-Onset Female Obesity in Finland

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

William Murphy
Wednesday, February 27, 2019
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  • Diet and the evolution of human amylase gene copy number variation.

  • Quarterly assessment of nutritional status and supplementation needs, food intolerances, and procedure-related symptoms should occur for the first year after bariatric surgery. Clinical, biochemical and genetic data for normal and obese subjects.

  • Podpryatov, Sergii S.

Introduction

Avoid nonsteroidal anti-inflammatory drugs. Enlarge Print Figure 1. PMID:

In the combined dataset each additional gene copy increased the concentration of total amylase by 3. Armenio M 3. PLoS One. The gender difference in AMY1 copy number and the biochemical effects of variable copy numbers is novel and merits further investigation in additional cohorts. Sci Rep10 121 Oct Our study does not suggest that higher copy numbers might be related to weight loss in obese persons or to maintenance of normal weight in controls. All obese and control individuals met the inclusion criteria, however at the time of study visit a few obese subjects had lost weight and a few controls had gained weight.

  • Muneyuki, T.

  • Competing interests: The authors have declared that no competing interests exist. Effect of dietary macronutrients on postprandial incretin hormone release and satiety in obese and normal-weight women.

  • Table 3 Association of AMY1 copy number with total and salivary concentration in the four subgroups obese men, obese women, control men, control women.

  • Even though progress has been made in this way, the genetic factors contributing to childhood-onset obesity are still poorly characterized.

  • Data on lifestyle factors was collected with a questionnaire. Hollox, E.

The gender difference in AMY1 copy surgedy and the biochemical effects of variable copy numbers is novel and merits further investigation in additional cohorts. Age- and sex-matched controls were selected from the national population register; similar to obese subjects, the controls were from the greater Helsinki area. Abstract The human salivary amylase genes display extensive copy number variation CNVand recent work has implicated this variation in adaptation to starch-rich diets, and in association with body mass index. Omar B. Chatterton, R. Conclusions In conclusion, our findings suggest that AMY1 copy number differences play a role in childhood-onset obesity but the effect differs between males and females. Multivitamin with minerals including iron, folic acid, copper, and thiamine.

Figure 5. Measurements amy1 obesity surgery BMI were obtained at study visit; some subjects with a history of severe childhood obesity had improved BMI. In each obesiity model, traits were analyzed as dependent variables whilst copy number and enzymatic activities were used as covariates. KN contributed to the overall study design. Diet and the evolution of human amylase gene copy number variation. Additional file 2: Clinical characteristics of participants included in the two obesity case-control studies. Age- and sex-matched controls were selected from the national population register; similar to obese subjects, the controls were from the greater Helsinki area.

Preoperative Considerations

Low serum amy1 obesity surgery in association with metabolic syndrome and diabetes: a community-based study. Google Scholar. First, chromosome structural variants are increasingly recognized to highly contribute to disease surgeryy [ 11 ], and thus the correct genotyping of multi-allelic copy number variant is mandatory [ 12 ]. Formal statistical significance was likely not reached in the obese subjects due to the small sample size. This would strengthen the correlations between the percentage of serum salivary amylase and serum pancreatic amylase and blood glucose after starch loading.

A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Rev Endocrinol. Gastric Pacemaker A device that electrically stimulates the nerves and muscles of the stomach to promote normal gastric movement. Ongoing participation in postsurgical support groups is highly recommended. Thus, an increase in AMY1 copy number increased the total amylase concentration by 3. A Stomach, duodenum, and jejunum before bariatric surgery. Impact of bariatric surgery on health care costs of obese persons: a 6-year follow-up of surgical and comparison cohorts using health plan data.

Weight regain is a concern in a subset of patients following weight loss surgery; the etiology suurgery to be multifactorial. Your email address is used only to let the recipient know who sent the email. Nat Genet. Measurements for BMI were obtained at study visit; some subjects with a history of severe childhood obesity had improved BMI. E-mail the story Saliva exonerated: Gene previously linked to obesity is unrelated, says new study. The obese and controls were initially age- and sex-matched but due to exclusion of subjects with incomplete data from the present study minor differences between the groups arose Table 1.

MeSH terms

Alternatively, healthy non-obese individuals with low AMY1 CNV who lack the perception for sweet obeslty may overeat, and an absent cephalic response to the early secretion of insulin may lead to a higher peak level of blood glucose after starch loading [ 67 ]. Our data suggests that low AMY1 copy number in obese young women might prevent from insulin resistance. Standards of medical care in diabetes Published online Jul 1.

Subjects Animal physiology Dietary carbohydrates Metabolic diseases. Alfa, R. Received Feb 28; Ssurgery Jun 8. Starchy foods are prominent components of the human diet, especially among agricultural societies. Metabolomic profiling to identify predictors of response to vitamin E for non-alcoholic steatohepatitis NASH. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Introduction Human obesity is a complex disorder affected by many interacting genetic and non-genetic factors. The bariatric surgeons at LI Obesity Surgery have performed thousands of bariatric procedures including vertical gastrectomies, gastric bypasses, revision surgeries and lap bands. This is the best decision I've ever made. J Nutrigenet Nutrigenomics. Affiliations 3 authors 1. In Roux-en-Y gastric bypass, a small gastric pouch is formed by dividing the upper stomach and joining it with the resected end of the jejunum, so that food bypasses the stomach and upper small bowel, thereby restricting the size of the stomach and causing some malabsorption Figure 3 Ethics declarations Competing interests The authors declare no competing financial interests.

  • Anthropometry including height, weight, and waist and hip circumferences was collected during the study visit, as described previously [ 21 ].

  • Sugandha Dhar.

  • All authors read and approved the final manuscript.

  • Metabonomics identified a BMI-independent association between AMY1 activity and lactate, a product of complex carbohydrate fermentation.

  • In a broader context the correlation between AMY1 copy number with serum and salivary amylase levels may elucidate the mechanism linking low copy numbers to female obesity.

Development and regulation of porcine pancreatic function. Diabetes Metab. Factors which decrease blood glucose concentrations following ingestion of a meal, independently of insulin, might help postpone insulin desensitization and slow the development of obesity amy1 obesity surgery delay the onset of type-2 diabetes. An explanation for this might be that lazy digestion of starchy foods provides composed elevation of plasma glucose. Low serum levels of amylase were found to be associated with an increased risk of insulin resistance 22 and diabetes 23 while high salivary amylase activity was associated with better glycemic homeostasis after starch ingestion In summary, the present study suggests extra-digestive enteral actions of pancreatic enzymes, specifically amylase and its derivatives, on blood glucose homeostasis.

Severe early-onset obesity, obesitu insufficiency and red hair pigmentation caused by POMC mutations in humans. Pancreatic enzyme activity in obese and lean Zucker rats: a developmental study. Accepted : 23 June Supporting Information S1 Table Clinical, biochemical and genetic data for normal and obese subjects. Journal of Biological Chemistry— Received Feb 28; Accepted Jun 8.

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Article PubMed Google Scholar Epigenetic marks of y predict adiposity in childhood. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression.

  • Experiments involving glucose tolerance tests performed in both intact and DJB pigs Fig. Low serum amylase in association with metabolic syndrome and diabetes: a community-based study.

  • Avoid nonsteroidal anti-inflammatory drugs.

  • BMC Med 15, 37 Reduced final height and indications for insulin resistance in 20 year olds born small for gestational age: regional cohort study.

Expert Rev Endocrinol Metab13 401 Jul Long-term mortality after gastric bypass surgery. Though other enzymes also perform this function, AMY1 begins this process in the saliva. Laboratory measurements Blood samples were obtained after an over-night at least 10 hours fast.

ALSO READ: Research Paper On Obesity Epidemic In America

Received : 15 August Show results from All journals This amy1 obesity surgery. An explanation for this might be that lazy digestion of starchy foods provides composed elevation of plasma glucose. Association analyses ofindividuals reveal 18 new loci associated with body mass index. Further reading ClinSV: clinical grade structural and copy number variant detection from whole genome sequencing data Andre E. Br J Nutr.

In DJB pigs, blood glucose and plasma insulin levels were higher following glucose loading into the by-passed biliopancreatic limb as compared to that following glucose loading orally or into the common intestinal limb. Amy1 obesity surgery pig is commonly accepted as an appropriate model for gastro-intestinal function in humans 35 External link. Table 3 Association of AMY1 copy number with total and salivary concentration in the four subgroups obese men, obese women, control men, control women. In conclusion, our findings suggest that AMY1 copy number differences play a role in childhood-onset obesity but the effect differs between males and females.

— "Clinically important" finding, says researcher

Marre, S. Explore citation contexts and check if this article has been supported or disputed. Type 2 diabetes mellitus.

  • Diet and the evolution of human amylase gene copy number variation. Show results from All journals This journal.

  • PLoS One.

  • Pediatric Clinics of North America 63—

Download references. Skip to main content Thank you for visiting nature. Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass. Figure 3. Lomberk, G.

From obesity genetics to the obesityy of personalized obesity therapy. Fedkiv, O. Additional file 1: D. BMC Med 15, 37 Diet and the evolution of human amylase gene copy number variation. Funding Statement The study was supported by grants from: the Academy of Finland grantwww. The potentiating influences of insulin on pancreozymin-induced hyperpolarization and amylase release in the pancreatic acinar cell.

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Amy supplementation will likely be required throughout the patient's lifetime, and annual metabolic and nutritional monitoring is recommended Table 5. Revision surgery is a procedure that follows a previous weight loss surgery that did not lead to the desired results. There is also more males than females with high number of copies, which is what would be expected if the gender difference is true.

However, the association is well supported by previous papers demonstrating that consumption quick carbohydrates such as sugar-sweetened beverages associates positively with measures of obesity and homeostasis model assessment HOMA index [ obeity20 ]. In the past decade genetic studies have increased our understanding of the mechanisms controlling energy balance. Article PubMed Google Scholar Enteral administration of amylase was also found to exert a direct influence on glucose disposal in pigs Copy number polymorphism of the salivary amylase gene: implications in human nutrition research. Obesity Surgery The Journal of nutrition—

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Enlarge Print. Adjust postoperative medications, as needed. Aitman, T. The association was further explored with linear regression.

This document is subject to copyright. Anthropometry including amy1 obesity surgery, weight, and waist and hip circumferences was collected during the study visit, as described previously [ 21 ]. Long-term mortality after gastric bypass surgery. So, H. Deweider and F.

Publication types

GTT in healthy growing pigs First, through studies on patients and animal models amy1 obesity surgery rare single gene defects in which obesity is the main phenotypic manifestation, several pathways and hormones regulating hunger and lipid metabolism have been identified [ 1 ]. Nakajima, K.

Surgery for weight loss in adults. Proc Nutr Surgeery. Vitamin D 3. Armenio M 3. This is an image hypoventilation obesity syndrome emedicine diverticulitis a weight scale. In conclusion, our findings suggest that AMY1 copy number differences play a role in childhood-onset obesity but the effect differs between males and females. Asked for his perspective, Mitchell Roslin, MD, chief of obesity surgery at Lenox Hill Hospital in New York City, who was not involved with the study, said: "These findings are most clinically meaningful and the methodology is very sound.

Article PubMed Xmy1 Scholar. Journal of animal science 90— Our results may suggest an alternative overlooked mechanism for the extra-digestive actions of amylase. A modification was made in order to ensure that insulin in the samples was within the detectable range. Blood glucose concentration after starch loading with a g rice ball was measured using a Glutest-Neo alpha glucose meter Sanwa-Kagaku-Kenkyusho, Nagoya, Japan. We aimed to re-assess the relationship between amylase and adiposity using a systems biology approach. Moreover, we had access to AMY2 plasma enzymatic activity at baseline for participants.

Most bariatric surgeries are performed laparoscopically; this is preferred to open procedures because of decreased mortality, fewer complications, shorter hospital stays, and more rapid recovery. Pancreatic enzyme activity in obese and lean Zucker rats: a developmental study. Preventive Services Task Force recommendation statement. Obese subjects had higher fasting glucose and insulin concentrations, resulting in higher HOMA index, indicating insulin resistance.

Associated Data

Gastroenterology— Thank you for visiting nature. PLoS One 9e When less salivary amylase is produced then the digestion of starchy carbohydrate rich foods takes longer inducing lower satiety and in consequence the impaired satiety may increase food intake. Diet and the evolution of human amylase gene copy number variation.

  • The gender difference in AMY1 copy number and the biochemical effects of variable copy numbers is novel and merits further investigation in additional cohorts.

  • Preventive Services Task Force recommendation statement.

  • Next, we took advantage of the prospective D.

  • N Engl J Med.

Data were available for 57 obese and 71 normal-weight controls. By contrast, only the total serum amylase concentration was inversely associated with BMI, which is consistent with our previous study [ 621 ]. Cell metabolism 21— However, we did not find any significant marginal association between AMY2A copy number and BMI, which makes unlikely a major role for pancreatic amylase gene. High salivary amylase activity could be expected to allow faster digestion and thus lead to higher postprandial blood glucose concentration, as seen in studies where oral digestion is fully avoided [ 29 ]. Figure 4. Only individuals presenting with these normal ranges were analyzed.

In addition, epigenetic mechanisms due to DNA methylation or histone modification of DNA in gene regulatory a,y1 may play a role in the pathogenesis of obesity [ 1011 ]. However, over the past 40 years a number of studies have reported evidence that insulin is directly involved in the regulation of exocrine pancreatic function 1234567. Characteristics of the Study Participants. Table 1 Baseline characteristics of subgroups with mean SD. All statistical analyses were carried out using the R v.

Our study does not suggest that higher copy numbers might obeslty related to weight loss in obese persons or to maintenance amy1 obesity surgery normal weight in controls. Table 1. Obese and control subjects were included in the present study if blood samples for DNA and serum analyses were available. Genomic copy number variants CNVs have emerged as important contributors to the genetic load in various disorders and several observations have suggested that CNVs may contribute to the heritability of complex diseases and common traits [ 13 ]. Traditional procedures such as hernia repair, appendectomy and acid reflux surgery are done laparoscopically, reducing hospital stay and recovery time. Evolution of genome architecture in archaea: spontaneous generation of a new chromosome in Haloferax volcanii Journal Article. For categorical variables Chi-Square test was applied.

Indications and Eligibility

All subjects were considered normoglycemic. Your friend's email. Public Health Nutr. Starchy foods are prominent components of the human diet, especially among agricultural societies. Here we investigated the clinical relevance of AMY1 copy number in a well-characterized, ethnically relatively homogeneous cohort of young adults with severe, early-onset obesity and compared the findings with a group of normal-weight age and sex-matched controls.

Download references. Measurements for BMI were obtained at study visit; some subjects with a history of severe childhood obesity had improved BMI. Skip to main content. Starch hydrolysis in man: an intraluminal process not requiring membrane digestion.

ALSO READ: Childhood Obesity Journal Reference Style

Adiposity and glucose intolerance exacerbate components of metabolic syndrome in children consuming sugar-sweetened beverages: QUALITY cohort study. PubMed Google Scholar. At first, the region looked "insanely complicated," said McCarroll. We identified significant association of a multi-allelic CNV encompassing the salivary amylase gene AMY1 with body mass index BMI and obesity, and we replicated this finding in 6, subjects. Our data here suggest that certain women on a western diet are unable to properly digest starchy foods and therefore prone to develop early-onset severe obesity. Associations were tested either with Pearson or Spearman correlation, and when adding in possible confounders age, genderwith partial correlations. Linkage disequilibrium and heritability of copy-number polymorphisms within duplicated regions of the human genome.

Close association of surgerry ductular and insular cells in the rat pancreas. Blood glucose and plasma insulin levels were monitored after intravenous, oral or direct gut glucose tolerance tests GTT in 6 pigs with an intact gastrointestinal tract and in 12 pigs following duodenal-jejunal bypass DJB surgery. Abstract The studies presented were designed to highlight the impact of pancreatic enzymes on glycemic control and insulin response. Cell Metab. Our study adds to the accumulating evidence and suggests that amylase may be an important factor in the regulation of glucose metabolism and consequently insulin secretion Figs 2B and 4B and thus may have an impact on obesity development and onset of diabetes. American Diabetes Association. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Instructions for Authors

Low AMY1 gene copy number is associated obedity increased body mass index in prepubertal boys. As expected, all anthropometric measures were greater amy1 obesity surgery obese subjects than in the controls. Consent for publication Not applicable. In contrast, in French middle-aged adults from the general population, we failed to reproduce these findings. Results Experiment I - Effect of oral enzyme pre-treatment on glucose tolerance tests in intact pigs Intravenous glucose tolerance test Blood glucose levels in intact pigs Fig.

However, the AMY1 copy number status affected total and salivary amylase concentrations differently in the four subgroups. Genomic copy number variants CNVs have emerged as important contributors to the genetic load in various disorders and several observations have suggested that CNVs may contribute to the heritability of complex diseases and common traits [ 13 ]. Clinical assessment Data on lifestyle factors was collected with a questionnaire. Recent history Saved searches. DOCX Click here for additional data file.

Am1y metabolic correlates of body mass index. The characteristics of the participants are shown in Table 1 ; all of the parameters were within normal ranges. Nat Genet. Diet and the evolution of human amylase gene copy number variation. Counting copy number and calories. Get the most important science stories of the day, free in your inbox.

  • J Physiol Pharmacol 6055—59 Furthermore, high serum amylase activity was shown to be associated with decreased risk of metabolic syndrome and type 2 diabetes in a Japanese asymptomatic population [ 14 ].

  • Proposed criteria for the diagnosis of diabetes: evidence from a French epidemiological study D.

  • American Diabetes Association.

  • DOC 28 kb.

  • Diabetes Research and Clinical Practice—

Individual amy1 obesity surgery in AMY1 gene copy number, salivary alpha-amylase levels, and the perception of oral starch. WHO Expert Consultation. Exclusion criteria. Vitamin supplementation will likely be required throughout the patient's lifetime, and annual metabolic and nutritional monitoring is recommended Table 5.

A frameshift mutation in MC4R associated with dominantly inherited human obesity. Our results uncover new patterns in human amylase variation and imply a potential role for AMY2 CNV in functional associations. Competing interests: The authors have declared that no competing interests exist. Our study does not suggest that higher copy numbers might be related to weight loss in obese persons or to maintenance of normal weight in controls. And when they ran their analyses on the genomes of about 4, Europeans with a range of body mass indexes, AMY1 had no association with higher or lower body mass index. In addition, an OVID Medline search was performed using the keywords obesity, bariatric weight loss, surgery, and diabetes.

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Amy1 obesity surgery because that region of the genome was so complicated, with AMY1 varying so widely from two to 14 or more copies per personhe wasn't sure his data told the whole story. Information from references 7 through 10161819and 21 through Asthma Stroke. Diet and the evolution of human amylase gene copy number variation. PLoS One.

High salivary amylase activity could be expected to allow faster digestion and thus lead to higher postprandial blood ssurgery concentration, as seen in amy1 obesity surgery where oral digestion is fully avoided [ 29 ]. At least 3, IU per day. People have different numbers of copies of the AMY1 gene and different amounts of the enzyme. High salivary amylase activity could be expected to allow faster digestion and thus lead to higher postprandial blood glucose concentration, as seen in studies where oral digestion is fully avoided [ 29 ].

Surgery variation in the human genome and its role in disease. Pancreatic islet-acinar cell interaction: amylase messenger RNA levels surgdry determined by insulin. In the past decade genetic studies have increased our understanding of the mechanisms controlling energy balance. The aim of the studies detailed below was to investigate whether pancreatic enzymes, in particular amylase, have more than just digestive consequences for glucose homeostasis. When we combined the two case-control studies in adults and youths, we identified a significant contribution of AMY1A copy number to lower obesity risk OR per estimated copy 0.

BARIATRIC SURGERY PROCEDURES

Serum levels of pancreatic enzymes in lean and obese subjects. Learn More. The lowest insulin release was observed after oral glucose gavage. Diabetes Care.

Pediatr Obes. A new highly penetrant form surgery obesity due to deletions on chromosome 16p It is unclear lbesity there is a significant long-term difference in weight loss between Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy Table 6 7 — 1016181921 — J Nutrigenet Nutrigenomics5 303 Sep The present study investigated the relationship between AMY1 copy number, BMI and serum amylase in childhood-onset obesity. Copin, O.

Surgery less salivary amylase is produced then the digestion of starchy carbohydrate rich foods takes longer inducing lower satiety and in consequence the impaired satiety may increase food intake. It appears that you are currently using Ad Blocking software. Born, E. Accessed October 27, Fig 3.

Associated Data

We also show that obwsity gender and obesity status influence the biochemical effect of the AMY1 copy number on total amylase and salivary amylase concentrations with the highest increase per copy noted in obese women and the lowest in obese men. Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass. Obesity Surgery

Supporting Information S1 Table Clinical, biochemical and genetic data for normal and obese subjects. Open in a separate window. Virtual consultations are available for new patients, as well as existing patients. Then she developed a statistical framework to find underlying patterns that explained the data. Administrator e-mail: openaccess nottingham. Copin, O. Conclusions In conclusion, our findings suggest that AMY1 copy number differences play a role in childhood-onset obesity but the effect differs between males and females.

Williams, J. Because the AMY1 copy number is associated with serum amylase it is likely to influence glucose metabolism directly by affecting the digestion of carbohydrates, starting in the mouth through salivary amylase. Fedkiv, O. Quarterly journal of experimental physiology 6935—39 In consistent with this, high levels of serum salivary amylase and a high percentage of salivary amylase in total serum amylase were associated with high blood glucose levels at an early stage after starch loading in this study. Livestock Science50—52

Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program

Accepted : 09 January surgery Biochemical findings Obese subjects surgety higher fasting glucose and insulin concentrations, resulting in higher HOMA index, indicating insulin resistance. The potentiating influences of insulin on pancreozymin-induced hyperpolarization and amylase release in the pancreatic acinar cell. Supporting Information S1 Table Clinical, biochemical and genetic data for normal and obese subjects.

BioStudies: supplemental material and supporting data. No evidence for association of body mass index with salivary amylase gene copy number in the UK Durgery Cohort Journal Article. Epigenetic marks of y predict adiposity in childhood. General Surgery Traditional procedures such as hernia repair, appendectomy, and acid reflux surgery are done laparoscopically, reducing hospital stay and recovery time. High Cholesterol. Results Background characteristics The final study cohort consisted of 61 32 males and 29 females obese subjects and 71 32 males and 39 females controls. Recent Activity.

This study makes use of data generated by the Genome Structural Variation Consortium principal investigators N. Fig 2. Individuals with obesity who opted for bariatric surgery to reduce sirgery weight appeared to get an added benefit of a markedly reduced risk of stroke, a difference that can be measured as early as a year after undergoing the procedure, researchers reported. You are using a browser version with limited support for CSS. J Nutr. Strong positive correlation between AMY1 copy number and total and salivary amylase concentrations was found both in the whole cohort and in the subgroups separately Table 2Fig 3. PMID:

Table 1 Baseline characteristics of subgroups with mean SD. Mark G. Learn more. Here we investigated the clinical relevance of AMY1 copy number in a well-characterized, ethnically relatively homogeneous cohort of young adults with severe, early-onset obesity and compared the findings with a group of normal-weight age and sex-matched controls. Andersson-Assarsson JC 2. Note Your email address is used only to let the recipient know who sent the email.

All obese participants had been followed at Children's Hospital amy1 obesity surgery endocrine and common disorders underlying obesity had been excluded e. Statistical analyses Normality of variables was visually inspected in the whole cohort and subgroups. Availability of data and materials Clinical, metabolic, and genetic data are available according to the rules of each individual cohort and can be requested from the D. Discussion Here, we demonstrate a link between the AMY1 copy number polymorphism and early onset obesity in females.

GiraultBichat Hospital Paris: F. A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease. Human obesity is a complex disorder affected by many interacting genetic obeskty non-genetic factors. Association analyses of lipid traits were performed in participants who did not use any lipid-lowering drugs at baseline. Our study does not suggest that higher copy numbers might be related to weight loss in obese persons or to maintenance of normal weight in controls. Conclusions In conclusion, our systems biology study performed in a prospectively followed population-based European cohort suggests a bidirectional relationship between AMY1 plasma enzymatic activity and adiposity. Nat Genet.

  • Published online Jul 1.

  • Aitman, T.

  • Fig 1. Associated Data Supplementary Materials S1 Table: Clinical, biochemical and genetic data for normal and obese subjects.

  • Gut 22—

  • Obesity Facts.

Serum levels of pancreatic enzymes in lean and obese subjects. In addition, a weak but non-significant positive association between HOMA index and AMY1 copy number was identified exclusively in obese women. Populations with high starch consumption carry larger number of copies than others that have maintained an ancestral pre-agricultural way of life [ 2 ]. We have also shown that the administration of oral bacterial amylase caused a reduction in insulin response to an i.

Worldwide, more than surgert, bariatric procedures were performed in Anthropometry including height, weight, and waist and hip circumferences was collected during the study visit, as described previously [ 21 ]. PLoS One11 5 :e, 05 May Twin Res. Our data suggests that low AMY1 copy number in obese young women might prevent from insulin resistance. The distribution of AMY1 copy number in the four groups of obese and control men and women is shown in Fig 1.

Background

In the present study, we only analyzed 36 metabolites previously shown to be associated with BMI [ 23 ], including 1,5-anhydroglucitol, 1-oleoylglycerophosphocholine2-hydroxybutyrate, 2-linoleoylglycerophosphocholine, 3- 4-hydroxyphenyl lactate, 3-hydroxyisobutyrate, 3-methyloxobutyrate, 3-methyloxovalerate, 4-methyloxopentanoate, 7-alpha-hydroxyoxocholestenoate, alpha-hydroxyisovalerate, andro steroid monosulfate 2, asparagine, benzoate, butyrylcarnitine, carnitine, ogesity, gamma-glutamyltyrosine, glutamate, glycerol, glycine, hexanoylcarnitine, histidine, isoleucine, isovalerylcarnitine, kynurenine, lactate, lathosterol, leucine, mannose, N-acetylglycine, palmitoyl sphingomyelin, phenylalanine, propionylcarnitine, tyrosine, and valine. In conclusion, our systems biology study performed in a prospectively followed population-based European cohort suggests a bidirectional relationship between AMY1 plasma enzymatic activity and adiposity. Informed consent was obtained from each subject before participation in the study, in accordance with the Declaration of Helsinki principles. Further, our data implies that AMY1 gene copies are less functional in obese men than in obese women. Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children.

Amy1 obesity surgery and S. A frameshift mutation in human MC4R is associated with a dominant form of obesity. All prices are NET prices. Study subjects This study was designed to assess metabolic, skeletal, and genetic characteristics of severe childhood-onset obesity.

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This is an open access article distributed under the surgey of the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Data Availability: All relevant data are within the paper and its Supporting Information files. The content is provided for information purposes only. Cited by: 47 articles PMID: Weight regain is a concern in a subset of patients following weight loss surgery; the etiology appears to be multifactorial. In addition, a weak but non-significant positive association between HOMA index and AMY1 copy number was identified exclusively in obese women. Results Background characteristics The final study cohort consisted of 61 32 males and 29 females obese subjects and 71 32 males and 39 females controls.

Earlier studies amy1 obesity surgery identified an increased risk of obesity in individuals with low AMY1 copy numbers [ 1417 ]. PLoS One11 5 :e, 05 May In addition, an OVID Medline search was performed using the keywords obesity, bariatric weight loss, surgery, and diabetes. John A.

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