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Hypogonadism caused by steroids on line: Is Testosterone Replacement Therapy the Same as Steroids?

Investigation: JJR.

William Murphy
Monday, January 1, 2018
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  • Inhibition of pulsatile gonadotropin-releasing hormone release results in a decrease in luteinizing hormone and follicle-stimulating hormone Rahnema et al.

  • Human reproduction Oxford, England. Ongoing AAS abuse causes dramatic increases in plasma androgen levels that ultimately facilitate severe hypothalamic-pituitary-gonadal HPG -axis suppression due to negative feedback mechanisms involving testosterone and its metabolites [ 5 ].

  • The history of the development of anabolic-androgenic steroids. However, for some men these levels become abnormally low.

  • However, levels are naturally lower in women than in men. How to Make Lavender Tea.

Publication types

This generally means using the smallest dose needed to help increase testosterone levels in your bloodstream. Your doctor may ask you to stop certain drugs before your test. The main symptoms of ASIH are low endogenous testosterone levels, gynecomastia, testicular atrophy, sexual dysfunction, hepatic dysfunction, and alopecia.

  • If you have testosterone replacement therapy, you will need frequent blood tests to check your testosterone levels and to check for side effects.

  • Our findings were that a high proportion of former AAS abusers were below the reference limit for eugonadal nonobese healthy young men compared with none of the control participants, but only 3.

  • And why it can help you sleep. The history of the development of anabolic-androgenic steroids.

  • Investigation: JJR. This emerging group of young men may become a considerable public health concern in the coming years.

  • In order to know whether testosterone levels are too low, a normal level has to be established.

However, according to a press release from the Endocrine Society in Januaryresults from a recent study have helped to plastic wrap your stomach to lose weight the definition of normal ranges for testosterone levels in men. For example, testosterone is responsible for the development of the penis and testes, voice deepening during puberty, and facial and pubic hair growth. Pharmacology of anabolic steroids. No potential conflict of interest relevant to this article was reported. Dying to be big: a review of anabolic steroid use. Medically reviewed by Femi Aremu, PharmD.

For potential or actual medical emergencies, lie call or your local emergency service. What could I ask a Dr to look for? Plasma total and free testosterone levels were significantly lower among former AAS abusers than among control participants and current AAS abusers, the latter of whom exhibited significantly increased plasma testosterone levels, as expected. Allison PD.

Connect with a doctor now. The questionnaire is highly validated and consists of five questions scored using a scale ranging from 1 to 5. Content on HealthTap including answers should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship.

We take a broad approach to your health, which means we evaluate you for underlying causes of your symptoms. However, the use of AAS was not free from the characteristic sequelae of the use of androgen and resulted in an unfavorable side effect of anabolic steroid-induced hypogonadism ASIH. Men have higher levels of testosterone than women. If you buy through links on this page, we may earn a small commission. This generally means using the smallest dose needed to help increase testosterone levels in your bloodstream. Testosterone replacement therapy can help men with low testosterone who experience symptoms like low libido, fatigue, weight gain, and even difficulty concentrating.

  • These include:. Increasing testosterone Testosterone boosters Testosterone food Replacement therapy Injections Side effects Testosterone levels Low testosterone Symptoms Testosterone test Causes in men Testosterone in women Takeaway We include products we think are useful for our readers.

  • Anabolic androgenic steroid-induced hypogonadism ASIH is common among former AAS abusers and usually presents as hypogonadotropic hypogonadism due to abrupt decreases in plasma androgen levels following AAS cessation [ 1258 ].

  • Anabolic steroid-induced hypogonadotropic hypogonadism.

  • Br J Pharmacol.

The participants volunteered hypogonaeism the community and were not patients from our clinic, but we cannot exclude the possibility that this study may have been plastic wrap your stomach to lose weight by selection bias. Investigation: JJR. Topics Catalog. Further, among former AAS abusers 3. We did not calculate overall average AAS doses in the AAS participants because the pharmacodynamics and pharmacokinetics of AAS compounds can vary considerably depending on their chemical structures [ 1 ]. For these, please consult a doctor virtually or in person.

Anabolic steroid abuse by body lins and male subfertility. However, the characteristics of the three groups were generally comparable with respect to important demographic parameters. The results of the present study are generally consistent with those of the recent study by Kanayama et al. All blood samples were then collected via a cannula in the right median cubital vein. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other abusable medications.

Unfortunately, this abusive use of anabolic-androgenic steroids has given testosterone replacement therapy a oh rap due to symptoms of too much testosterone and other chemicals in steroids. It usually decreases, particularly for men aged 30 years and older. Some symptoms can have an impact on your quality of life. From a legal standpoint, this is the difference between testosterone therapy and illegal steroids.

Find out sterodis the blood test means and who it's…. Line people view testosterone this way due to illegal anabolic steroid use. You can purchase a test kit online from LetsGetChecked here. Testosterone levels in men usually peak around the age of 19 years. This is a medical treatment often used to help men suffering from low testosterone. J Int Soc Sports Nutr. The reality is that because of simple greed, four of five people use AAS to improve their appearance Cohen et al.

Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. Exclusion criteria for the three groups were: congenital hypogonadal hypoyonadism, medically prescribed testosterone therapy, known cardiovascular disease and diabetes mellitus. We did not calculate overall average AAS doses in the AAS participants because the pharmacodynamics and pharmacokinetics of AAS compounds can vary considerably depending on their chemical structures [ 1 ]. Medicine and science in sports and exercise.

Discussion The key findings of this study were that the group of former AAS abusers exhibited significantly lower plasma total and free testosterone, smaller testicular sizes, and featured a higher proportion of hypogonadism caused by steroids on line with depressive symptoms, fatigue, erectile dysfunction and decreased libido than the control group more than two years after AAS cessation. Get help now: Ask doctors free Educational text. This study had several limitations which should be addressed. We did not apply specific inclusion criteria regarding weekly hours of recreational strength training, nor did we apply inclusion criteria pertaining to the extent of AAS abuse. Effects of supraphysiologic doses of testosterone on mood and aggression in normal men: a randomized controlled trial.

  • Then, we create a personalized treatment plan based on your condition and life.

  • Symptoms suggestive of functional hypogonadism in the three groups.

  • The main symptoms of ASIH are low endogenous testosterone levels, gynecomastia, testicular atrophy, sexual dysfunction, hepatic dysfunction, and alopecia.

  • As we age, however, testosterone levels naturally start to decline. The Anabolic survey: characteristics of male users versus nonusers of anabolic-androgenic steroids for strength training.

  • Scand J Med Sci Sports.

  • Long-term side effects include organ damage. Testosterone replacement therapy can help energy levels, mood, and more.

Additionally, participants were recruited from the same communities, which were primarily located in the greater Copenhagen area. Lower scores were suggestive of more pronounced fatigue symptoms [ 30 ]. We used piecewise linear regression linear splinesallowing varying slopes, to model nonlinear associations. First could be seen the retreat of testicular atrophy followed by the rearrangement of spermatogenesis. Anabolic steroid-induced hypogonadism: diagnosis and treatment. These findings indicate AAS abuse is now prevalent in the broader population.

Substances Testosterone Congeners. Plasma total and free testosterone levels were significantly lower among former AAS abusers than among control participants and current AAS abusers, the latter of whom exhibited significantly increased plasma testosterone levels, as expected. Fig 6. Eleven former AAS abusers had previously been referred to an endocrine clinic for gynaecomastia, but none had been treated for gynaecomastia, hypogonadism or infertility. S2 Table. Pope HG Jr. Get help now: Ask doctors free Educational text.

When to Consider a Testosterone Test. Anabolic steroid-induced hypogonadotropic hypogonadism. J Urol. However, levels that are too high may cause unwanted symptoms. The pathophysiology of ASIH can be explained by the fact that AAS induces feedback suppression of the hypothalamic-pituitary-gonadal axis.

In women, most testosterone is made in the ovaries. Since the introduction of oral methyltestosterone inthe use of synthetic androgen has started in earnest. What is testosterone? The opinions expressed herein do not necessarily reflect those of Low T Center. Adding resistance exercise and losing weight are two changes that can have an effect.

Adverse health consequences of performance-enhancing drugs: an Endocrine Society scientific statement. Drs agree Gy have hypogonadism. Company Blog. Key words: anabolic steroids - doping - hypogonadotropic hypogonadism hypogonadism caused by steroids on line side effects. Data Availability: The participants in this study are guaranteed to remain completely anonymous. These findings suggest a rather high proportion of former AAS abusers exhibit testosterone levels in the low area of the normal range years after AAS cessation, whereas only a small proportion of former AAS abusers exhibit persistently marked low testosterone levels. Exclusion criteria for the three groups were: congenital hypogonadal conditions, medically prescribed testosterone therapy, known cardiovascular disease and diabetes mellitus.

Medically reviewed by Femi Aremu, PharmD. They use your saliva to test your caussd levels. J Urol. This can increase testosterone and other hormone levels beyond the natural limit and can put your health at risk. By contrast, because steroid abusers use drugs illegally and without a prescription, there is no medical oversight for safety.

We did not obtain sperm samples which could have provided valuable information regarding fertility among the participants. Substances Steoids Congeners. The 2. The users mainly well informed from internet use for amelioration of the symptoms injections of human choriogonadotropin hCGselective estrogen receptor modulators SERM or aromatase inhibitors. However, information regarding the impact of AAS abuse on these reproductive hormones is very limited [ 67 ].

Medically reviewed by Daniel Murrell, M. By contrast, men using testosterone replacement therapy generally receive continuous doses to keep baseline, optimized levels. This can increase testosterone and other hormone levels beyond the natural limit and can put your health at risk. You need them less frequently than other forms. Br J Sports Med. However, for some men these levels become abnormally low.

If you have testosterone replacement therapy, you will need frequent blood tests to check your testosterone levels and to check for side effects. For this treatment, testosterone medication is prescribed. However, TRT is a legal, prescribed treatment for conditions like low testosterone. In women, most testosterone is made in the ovaries. When you think of testosterone, what comes to mind?

  • After the age of 30 years, these levels begin to naturally decrease in all men.

  • Association between accumulated duration of AAS abuse log 2 scale and plasma total testosterone levels log 2 scale in former AAS abusers. A few minor studies have investigated sperm counts and morphology in current AAS abusers only and noted severe impairment [ 3536 ].

  • Anabolic steroids purchased on the Internet as a cause of prolonged hypogonadotropic hypogonadism. However, these drugs often also include other chemicals that aim to enhance physical performance or appearance.

  • Fig 2.

  • The symptoms we observed among former AAS abusers may have been a consequence of abrupt decreases in plasma androgens, from supraphysiologic levels to low or normal levels, following AAS withdrawal, as opposed to specific plasma testosterone levels. Symptoms of depression, erectile dysfunction and decreased libido in the three groups.

Before you reach for testosterone boosting supplements, get the facts on what these products really are and whether or not they'll benefit your health. Br J Pharmacol. Symptoms of high testosterone in women may be an indication of an underlying condition that needs to be treated. Testosterone injections are one of the more common forms of testosterone replacement therapy. The reality is that because of simple greed, four of five people use AAS to improve their appearance Cohen et al. It helps increase muscle bulk, bone mass, physical strength, and the amount of body hair. However, no standard and regulation have been established for public use of AAS yet.

We conducted a community-based cross-sectional case-control study in the greater Copenhagen area from November to December And i was needing to know if my hypogonadism is reversible or not, based on my test results. Combined effects of androgen anabolic steroids and physical activity on the hypothalamic-pituitary-gonadal axis. Fig 5.

REFERENCES

Product What We Treat. We also have no evidence that participants in the groups of current and former AAS abusers were similar to the control group before starting AAS abuse. Download: PPT. We did not observe any associations between these symptoms and reproductive hormone levels. When diagnosed, the crucial step in the therapy is the stop of anabolic use.

All participants were aged 18—50 years and were involved in recreational strength training. Related topics Sterlids. Journal of clinical epidemiology. Combined effects of androgen anabolic steroids and physical activity on the hypothalamic-pituitary-gonadal axis. Participants and Methods Study Design and Participants We conducted a community-based cross-sectional case-control study in the greater Copenhagen area from November to December Abstract Aims Abuse of anabolic androgenic steroids AAS is highly prevalent among male recreational athletes.

Genital examination revealed that both testicular volumes were reduced to 13 ml. PLoS One. He had been abusing androgenic anabolic steroids AAS for 7 years. However, the characteristics of the three groups were generally comparable with respect to important demographic parameters.

Ssteroids September 9, When you think of testosterone, what comes to mind? They are typically given by a doctor. It also affects sexual desire. Results of one study in rats fed diets that were supplemented with garlic or a compound found in garlic noted an increase in testosterone levels in the testicles.

Treatment of anabolic-androgenic steroid dependence: Emerging evidence and its implications. Therefore, the results of this steroifs may simply reflect differences among three groups that were already present at baseline. Lower scores were suggestive of more pronounced fatigue symptoms [ 30 ]. Is secondary hypogonadism caused by anorexia reversible? However, the characteristics of the three groups were generally comparable with respect to important demographic parameters. The 2. An important potential consequence of the anabolic steroid misuse is hypogonadotropic hypogonadism due to the inhibition of pituitary secretion of gonadotropins.

Testosterone side effects. Steroid abusers generally take much higher doses in order to achieve a certain physique. By contrast, steroid users generally use much higher doses than is recommended by a doctor. One treatment option for hypogonadism is testosterone replacement therapy TRT. Support Center Support Center. Med Sci Sports Exerc.

We did not observe any associations between these symptoms and reproductive hormone levels. Former AAS abusers exhibited the highest frequencies of participants with depressive symptoms Is secondary hypogonadism caused by anorexia reversible? Publication types Case Reports English Abstract.

AAS, anabolic androgenic steroids. ASIH may become a public health concern with respect to male infertility and hypogonadism. We acknowledge the personnel in the endocrine research lab of Herlev Hospital for providing highly qualified technical assistance. Formal analysis: JJR.

Anabolic steroid-induced hypogonadotropic hypogonadism. Fig 5. For these, please consult a doctor virtually or in person. Investigation: JJR. J Urol. First could be seen the retreat of testicular atrophy followed by the rearrangement of spermatogenesis.

Hypogonadism: There are many causes of hypogonadismtoo numerous to enumerate here. Content on HealthTap including answers should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Video chat with a U. Med Hypotheses. Combined effects of androgen anabolic steroids and physical activity on the hypothalamic-pituitary-gonadal axis. Drug Alcohol Depend. Two smaller studies measured serum inhibin B in current AAS abusers and reported levels similar to those measured in current AAS abusers in this study [ 67 ].

Many people view testosterone this way due to illegal anabolic steroid use. How to Make Lavender Tea. In men, most testosterone is made in the testes. Many think of unnaturally large muscles and aggressive behavior. What Is Testosterone?

There may be certain lifestyle changes to help increase testosterone levels. Some foods may play a role in helping your body moderate your testosterone levels. When you think of testosterone, what comes to mind? Since the introduction of oral methyltestosterone inthe use of synthetic androgen has started in earnest.

ALSO READ: Wellbutrin And Adderall Weight Lose

Can metabolic syndrome cause hypogonadism. Hypogonadism revesable? Kanayama et al. The participants volunteered from the community and were not patients from our clinic, but we cannot exclude the possibility that this study may have been affected by selection bias. Further, among former AAS abusers 3. In this study all former AAS abusers exhibited plasma SHBG within the normal reference range and excludes that oral AAS were abused in this group while injections with testosterone could possibly still have been used.

Combined effects of androgen anabolic steroids and physical activity on the hypothalamic-pituitary-gonadal axis. Convalescence lasts usually several months or even more than one year. AAS, anabolic androgenic steroids. Footnote: AAS, anabolic androgenic steroids; s-serum. These findings indicate AAS abuse is now prevalent in the broader population.

Numerical variables were compared across the groups by analysis of variance ANOVA and presented as mean standard error if the assumptions of a normal distribution and equality of variance were fulfilled. Am J Sports Med. Combined effects of androgen anabolic steroids and physical activity on the hypothalamic-pituitary-gonadal axis. Anabolic androgenic steroids: a survey of users. Steroid use very certainly among the causes.

We did not observe any significant associations between symptoms and hormonal levels or extent of AAS abuse among former AAS abusers. There are many severe side effects of abusing AAS and thus education about the severe side effects of AAS abuse is necessary. Additionally, participants were recruited from the same communities, which were primarily located in the greater Copenhagen area. Could hypogonadism cause my polyuria? Handling Missing Data by Maximum Likelihood.

Table 1. Anabolic steroid induced hypogonadism in young men. A recent meta-analysis estimated the lifetime prevalence of AAS abuse worldwide is 6. Effects of supraphysiologic doses of testosterone on mood and aggression in normal men: a randomized controlled trial. Disclaimer: Content on HealthTap including answers should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Sexual dysfunction was frequently noted among former AAS abusers and could have biased the semen results, as these participants would likely not have been able to provide semen samples or may have even refused to participate in the study.

  • How to Make Lavender Tea. And why it can help you sleep.

  • The study was performed in accordance with the Declaration of Helsinki and all relevant legal regulations in Denmark.

  • J Urol.

  • Data Availability: The participants in this study are guaranteed to remain completely anonymous.

  • However, in some men, these levels can be too low and cause unwanted symptoms. However, for some men these levels become abnormally low.

Effect of androgenic anabolic steroids on semen parameters and steroiids levels in bodybuilders. Fig 4. They were placed in the supine position for a minimum of 30 minutes. We noted a high proportion of former AAS abusers exhibiting symptoms suggestive of functional hypogonadism. To our knowledge, no studies have previously investigated the fertility or biomarkers of Sertoli-cell function in former AAS abusers. Drug Alcohol Depend. Low reference limits 2.

We used piecewise linear regression linear splinesallowing varying slopes, to model nonlinear associations. Abstract Aims Abuse of anabolic androgenic steroids AAS is highly prevalent among male recreational athletes. Sexual dysfunction was frequently noted among former AAS abusers and could have biased the semen results, as these participants would likely not have been able to provide semen samples or may have even refused to participate in the study. J Steroid Biochem Mol Biol.

In addition, such high doses can cause side effects like paranoid jealousy, aggression, delusions, mania, and impaired judgement. Unfortunately, this abusive use of anabolic-androgenic steroids has given testosterone replacement therapy a bad rap due to symptoms of too much testosterone and other chemicals in steroids. Because of the difference in dose and sometimes chemical composition of TRT and steroids, this leads to different potential side effects. Additionally, these products are not closely regulated by the U.

These participants did not differ hypogonadism caused by steroids on line other former AAS abusers in terms of demographic characteristics, AAS abuse, laboratory results or frequency of hypogonadal symptoms. A total of 37 current AAS abusers, 33 former AAS abusers and 31 control participants volunteered to participate in the study. International journal of impotence research. Can hypogonadism be caused by a varicoecele? All participants were aged 18—50 years and were involved in recreational strength training. Sinnecker G, Kohler S. Content on HealthTap including answers should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship.

We first forbade him to use AAS, but the symptoms and endocrinological features were not improved. Table 1. Nevertheless, this difference may have impacted fertility among former AAS abusers at a population level. Fertility Medicine 34 years experience.

However, for some men these levels become abnormally low. In other words, as we often think or as coverage by mass media, AAS is not the problem of other worlds that only professional athletes use. Testosterone side effects.

From a legal steroids line, this is the difference between testosterone therapy and illegal steroids. Testosterone decreases each year after age Testosterone is a hormone found in men, less so in women. Several foods might be helpful for increasing your T level — a few may surprise you. Anabolic steroid-induced hypogonadism: diagnosis and treatment. AAS is purchased through the Internet, and Internet suppliers sell bundled packages, including selective estrogen receptor modulators SERMsaromatase inhibitors, human chorionic gonadotropin hCGand phosphodiesterase-5 inhibitors Cordaro et al.

  • By contrast, because steroid abusers use drugs illegally and without a prescription, there is no medical oversight for safety. There are several differences between using medical testosterone and abusing steroids.

  • Sex hormone-binding globulin response to the anabolic steroid stanozolol: evidence for its suitability as a biological androgen sensitivity test.

  • Anabolic steroids purchased on the Internet as a cause of prolonged hypogonadotropic hypogonadism. Here are eight healthy options for….

  • Anabolic steroid-induced hypogonadism: diagnosis and treatment. Former AAS abusers exhibited the highest frequencies of participants with depressive symptoms

Sexual dysfunction was frequently noted among former AAS abusers and could have biased the semen results, as these participants would likely not have been able to provide semen samples or may have even refused to participate in the study. Former AAS abusers exhibited significantly lower plasma testosterone levels and higher frequencies of symptoms suggestive of hypogonadism than healthy control participants years after AAS cessation. Clinical journal of sport medicine: official journal of the Canadian Academy of Sport Medicine. Pope HG Jr. Former AAS abusers exhibited the highest frequencies of participants with depressive symptoms Footnote: AAS, anabolic androgenic steroids; s-serum.

Eleven former AAS abusers had previously been referred to an endocrine clinic for gynaecomastia, dteroids none had been treated for hypogonadism caused by steroids on line, hypogonadism or infertility. Abstract Aims Abuse of anabolic androgenic steroids AAS is highly prevalent among male recreational athletes. Furthermore, it is possible that post-cycle therapy may have reduced the frequency of impaired spermatogenesis in the group of former AAS abusers. Journal of clinical epidemiology. Drs agree I have hypogonadism. Participants were recruited primarily from fitness centres in the greater Copenhagen area and by internet advertising.

By contrast, steroid abuse is the illegal xteroids of anabolic-androgenic steroids to try to increase muscle mass or athletic performance. When to Consider a Testosterone Test. Try out PMC Labs and tell us what you think. It plays a role in puberty and fertility. After the age of 30 years, these levels begin to naturally decrease in all men.

Video chat with a U. The participants hypogonadusm from the community and were not patients from our clinic, but we cannot exclude the possibility that this study may have been steroids line by selection bias. Changes in anti-Mullerian hormone AMH throughout the life span: a population-based study of healthy males from birth cord blood to the age of 69 years. We conducted a community-based cross-sectional case-control study in the greater Copenhagen area from November to December Overall, Call your doctor or if you think you may have a medical emergency.

We also have no evidence that participants in the groups of current and former AAS abusers were similar to the control group before starting AAS abuse. Abuse of anabolic androgenic steroids AAS is highly prevalent among male recreational athletes. Introduction Anabolic androgenic steroids AAS comprise testosterone and its synthetic derivatives. Anabolic steroid induced hypogonadism in young men. We acknowledge the personnel in the endocrine research lab of Herlev Hospital for providing highly qualified technical assistance. Association between elapsed duration since AAS cessation log 2 scale and plasma total testosterone levels log 2 scale in former AAS abusers.

By contrast, men using testosterone replacement therapy generally receive continuous doses to keep baseline, streoids levels. They use your saliva to test your hormone levels. Garlic has also been credited for increased testosterone levels. What we commonly refer to as steroids do contain androgens such as testosterone. For example, testosterone is responsible for the development of the penis and testes, voice deepening during puberty, and facial and pubic hair growth.

Support Center Support Center. It helps increase muscle bulk, bone mass, physical strength, and the amount of body hair. Testosterone levels in men decrease a little naturally with age. External link. Research has indicated that resistance exercise, such as lifting weights, is related to temporary increases in testosterone levels.

Garlic has also been credited for increased testosterone levels. This is generally attributed to the extreme doses, mixes of other chemicals, and lack of medical guidance when using steroids. In young men, hypogonadism not only is a problem but also can cause a more serious problem such as infertility. Since AASs began to be used by Olympic athletes to improve performance in the s, associated sports issues have emerged and now expanded to public health issues issues Franke and Berendonk, Long-term side effects include organ damage.

We did not calculate overall average AAS doses in the AAS participants because the pharmacodynamics and pharmacokinetics of AAS compounds can vary considerably depending on their chemical structures [ 1 ]. Assumptions of normal distributions with respect to numerical variables were evaluated by histograms and by assessing the linearity of residuals in a quantile plot. The Journal of urology. When diagnosed, the crucial step in the therapy is the stop of anabolic use.

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